Gentile Eleonora, Ricci Katia, Delussi Marianna, Brighina Filippo, de Tommaso Marina
Applied Neurophysiology and Pain Unit, SMBNOS Department, Bari Aldo Moro University, Polyclinic General Hospital, Via Amendola 207 A, 70123 Bari, Italy.
Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Via del Vespro 143, 90127 Palermo, Italy.
Pain Res Treat. 2019 Jan 16;2019:2623161. doi: 10.1155/2019/2623161. eCollection 2019.
Previous studies indicated changes of motor cortex excitability in fibromyalgia (FM) patients and the positive results of transcranial stimulation techniques. The present study aimed to explore the metabolism of motor cortex in FM patients, in resting state and during slow and fast finger tapping, using functional Near-Infrared Spectroscopy (fNIRS), an optical method which detects in real time the metabolism changes in the cortical tissue. We studied 24 FM patients and 24 healthy subjects. We found a significant slowness of motor speed in FM patients compared to controls. During resting state and slow movement conditions, the metabolism of the motor areas was similar between groups. The oxyhemoglobin concentrations were significantly lower in patients than in control group during the fast movement task. This abnormality was independent from FM severity and duration. The activation of motor cortex areas is dysfunctional in FM patients, thus supporting the rationale for the therapeutic role of motor cortex modulation in this disabling disorder.
先前的研究表明纤维肌痛（FM）患者运动皮层兴奋性发生了变化，以及经颅刺激技术取得了积极成果。本研究旨在使用功能性近红外光谱（fNIRS）这一光学方法，实时检测皮层组织中的代谢变化，来探索FM患者在静息状态以及缓慢和快速手指敲击过程中运动皮层的代谢情况。我们研究了24名FM患者和24名健康受试者。我们发现，与对照组相比，FM患者的运动速度明显较慢。在静息状态和缓慢运动条件下，两组之间运动区域的代谢情况相似。在快速运动任务期间，患者的氧合血红蛋白浓度显著低于对照组。这种异常与FM的严重程度和病程无关。FM患者运动皮层区域的激活存在功能障碍，因此支持了运动皮层调制在这种致残性疾病中发挥治疗作用的基本原理。
