CD5阳性原发性皮肤弥漫性大B细胞淋巴瘤-腿部型
CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type.
作者信息
Papoudou-Bai Alexandra, Marinos Leonidas, Vassou Amalia, Kapsali Eleni, Kanavaros Panagiotis
机构信息
Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Department of Hematopathology, Evangelismos General Hospital, Athens, Greece.
出版信息
Case Rep Dermatol Med. 2019 Jan 16;2019:3730915. doi: 10.1155/2019/3730915. eCollection 2019.
Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis.
大多数原发性皮肤B细胞淋巴瘤（PCBCL）为CD5阴性，仅发现少数病例表达CD5。我们报告首例有充分记录的CD5阳性原发性皮肤弥漫性大B细胞淋巴瘤-腿部型（PCDLBCL-LT）。一名有多发性硬化病史的71岁女性因左大腿出现结节入院。皮肤活检的组织学检查显示真皮有大淋巴细胞弥漫浸润。免疫组化显示这些大细胞CD5、CD20、CD79a、MUM1/IRF4、Bcl6、Bcl2和细胞质IgM/呈阳性，而未检测到CD3、CD56、CD23、CD21、CD10、CD30、细胞周期蛋白D1、CD68、溶菌酶、髓过氧化物酶和CD34。因此，诊断为CD5阳性PCDLBCL-LT。尽管进行了治疗，患者在初次诊断后11个月死亡。
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