Quesda J R
Section of Biological Therapy of Solid Tumors, MD Anderson Hospital.
Oncology (Williston Park). 1988 Mar;2(3):49-54.
Alpha interferons have shown significant antitumor activity against B-cell malignancies (especially hairy cell leukemia), and chronic myelogenous leukemia. They are also useful against malignant carcinoid tumors, renal cell carcinoma, and Kaposi's sarcoma. Alpha interferons are less effective against lung, liver, ovary, breast, and colon carcinoma. Side effects vary in severity according to type of interferon, route of administration, schedule, and dose. In general, tolerance and compliance are excellent with doses of one to nine million units per day.
α干扰素已显示出对B细胞恶性肿瘤（尤其是毛细胞白血病）和慢性粒细胞白血病具有显著的抗肿瘤活性。它们对恶性类癌肿瘤、肾细胞癌和卡波西肉瘤也有效。α干扰素对肺癌、肝癌、卵巢癌、乳腺癌和结肠癌的疗效较差。副作用的严重程度因干扰素类型、给药途径、用药方案和剂量而异。一般来说，每天使用100万至900万单位的剂量时，耐受性和依从性都很好。
