O'Dwyer P J, Cheson B D, Leyland-Jones B, King S A, Hoth D F
Fox Chase Cancer Center, Philadelphia, PA 19111.
Oncology (Williston Park). 1988 Jun;2(6):17-23, 26-7.
Promising results in the treatment of indolent lymphomas have been reported with the use of 2'deoxycoformycin. This antimetabolite, an adenosine deaminase inhibitor, also shows particular efficacy in hairy cell leukemia. Of 65 patients treated to date, 44 have achieved complete and lasting remission after a limited course of deoxycoformycin. While results are not as striking as those in hairy cell leukemia, deoxycoformycin may also be a valuable adjunct to alkylating agents in the treatment of CLL. The drug also is being studied in the treatment of mycosis fungoides and other lymphoid neoplasms. Side effects in all neoplasms are dose- and schedule-dependent.
据报道，使用2'-脱氧助间型霉素治疗惰性淋巴瘤取得了有前景的结果。这种抗代谢物作为一种腺苷脱氨酶抑制剂，在毛细胞白血病中也显示出特殊疗效。在迄今接受治疗的65例患者中，44例在接受有限疗程的脱氧助间型霉素治疗后实现了完全且持久的缓解。虽然结果不如在毛细胞白血病中那样显著，但脱氧助间型霉素在慢性淋巴细胞白血病的治疗中可能也是烷化剂的一种有价值的辅助药物。该药物也正在用于蕈样肉芽肿和其他淋巴瘤的治疗研究。在所有肿瘤中，副作用都取决于剂量和给药方案。
