喷他脒与甲氧苄啶-磺胺甲恶唑联合治疗大鼠卡氏肺孢子虫肺炎
Combination of pentamidine and trimethoprim-sulfamethoxazole in therapy of Pneumocystis carinii pneumonia in rats.
作者信息
Kluge R M, Spaulding D M, Spain A J
出版信息
Antimicrob Agents Chemother. 1978 Jun;13(6):975-8. doi: 10.1128/AAC.13.6.975.
Treatment with either pentamidine isethionate or trimethoprim-sulfamethoxazole significantly reduces the mortality of Pneumocystis carinii pneumonia. It is not known whether a combination might act in an additive, synergistic, or antagonistic manner. We studied the interaction of these two agents in the steroid-conditioned rat model of pneumocystosis. Of animals receiving pentamidine alone, 48% died and 45% had P. carinii cysts at autopsy. Trimethoprim-sulfamethoxazole alone resulted in 21% mortality, and cysts were found in 28%. Both agents in full doses resulted in 45% deaths and cysts in 37%. Animals treated with half-dosages of pentamidine plus trimethroprim-sulfamethoxazole had mortality of 35%, and 21% had cysts. Trimethoprim alone, in two dosages, was ineffective in eradicating P. carinii cysts. The data suggest that combination therapy is no more effective than trimethoprim-sulfamethoxazole alone in the treatment of P. carinii pneumonia.
用乙磺半胱氨酸戊烷脒或甲氧苄啶 - 磺胺甲恶唑治疗可显著降低卡氏肺孢子虫肺炎的死亡率。尚不清楚联合用药是相加、协同还是拮抗作用。我们在经类固醇处理的大鼠肺孢子虫病模型中研究了这两种药物的相互作用。单独接受戊烷脒治疗的动物中，48%死亡，45%在尸检时有卡氏肺孢子虫囊肿。单独使用甲氧苄啶 - 磺胺甲恶唑导致21%的死亡率，28%发现有囊肿。两种药物全剂量使用导致45%死亡，37%有囊肿。用半剂量戊烷脒加甲氧苄啶 - 磺胺甲恶唑治疗的动物死亡率为35%，21%有囊肿。两种剂量的单独甲氧苄啶在根除卡氏肺孢子虫囊肿方面均无效。数据表明，联合治疗在治疗卡氏肺孢子虫肺炎方面并不比单独使用甲氧苄啶 - 磺胺甲恶唑更有效。
Zotero 插件