5 年无病生存期后鼻窦癌的复发模式。

Recurrence patterns of sinonasal cancers after a 5-year disease-free period.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Soon Chun Hyang University Hospital, Soon Chun Hyang University, Seoul, South Korea.

Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

出版信息

Laryngoscope. 2019 Nov;129(11):2451-2457. doi: 10.1002/lary.27866. Epub 2019 Feb 22.

DOI:10.1002/lary.27866

PMID:30794325

Abstract

OBJECTIVES/HYPOTHESIS: Sinonasal cancers are rare but have a poor prognosis. Most previous studies of these cancers have focused on 5-year disease-free survival, but recurrences are also known to occur after this period. We examined the post-5-year recurrence patterns in sinonasal cancer patients by histologic type to determine the indicators for extended and close follow-up requirements.

STUDY DESIGN

Retrospective chart review.

METHODS

A cohort of 241 sinonasal cancer patients was included. Demographic data, cancer site and stage, pathology and treatment results, and follow-up and survival data were collected.

RESULTS

Of the 241 patients, a complete remission occurred in 163 (72.4%) patients, but 83 (50.9%) of these cases developed recurrence, which occurred beyond the 5-year follow-up period in 19 cases (11.7%). The most common post-5-year recurrences were adenoid cystic carcinoma (six patients, 33.3%), followed by melanoma (three patients, 21.4%), poorly differentiated carcinoma (two patients, 18.2%), squamous cell carcinoma (six patients, 6.7%), and olfactory neuroblastoma (no patients, 0%). Post-5-year local recurrence was highest in adenoid cystic carcinoma (six patients, 33.3%), followed by melanoma (three patients, 21.4%), poorly differentiated carcinoma (two patients, 18.2%), and squamous cell carcinoma (five patients, 5.5%). Post-5-year regional recurrence occurred in one squamous carcinoma patient (1.1%), and distant metastasis was seen in one adenoid cystic carcinoma patient (5.5%).

CONCLUSIONS

Sinonasal cancer shows an 11.7% recurrence rate after a 5-year disease-free period. As this recurrence pattern varies by tumor pathology, a specific follow-up plan is needed for each cancer type.

LEVEL OF EVIDENCE

3 Laryngoscope, 129:2451-2457, 2019.

摘要

目的/假设：鼻窦癌较为罕见，但预后较差。大多数关于鼻窦癌的既往研究都集中在 5 年无病生存率上，但也已知在此期间后会发生复发。我们通过组织学类型检查鼻窦癌患者的 5 年后复发模式，以确定需要延长和密切随访的指标。

研究设计

回顾性图表审查。

方法

纳入了 241 例鼻窦癌患者。收集了人口统计学数据、癌症部位和分期、病理和治疗结果以及随访和生存数据。

结果

在 241 例患者中，163 例（72.4%）患者完全缓解，但其中 83 例（50.9%）出现复发，19 例（11.7%）在 5 年随访期后发生复发。最常见的 5 年后复发是腺样囊性癌（6 例，33.3%），其次是黑色素瘤（3 例，21.4%）、低分化癌（2 例，18.2%）、鳞状细胞癌（6 例，6.7%）和嗅神经母细胞瘤（无，0%）。腺样囊性癌 5 年后局部复发率最高（6 例，33.3%），其次是黑色素瘤（3 例，21.4%）、低分化癌（2 例，18.2%）和鳞状细胞癌（5 例，5.5%）。1 例鳞状细胞癌患者发生 5 年后区域复发（1.1%），1 例腺样囊性癌患者发生远处转移（5.5%）。