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复发性鼻窦鳞状细胞癌:当前见解与治疗进展

Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances.

作者信息

Kravitz Meryl B, Annadata Vivek, Ilyaev Benjamin, Tong Charles C L, Fastenburg Judd H, Chaskes Mark B

机构信息

Department of Otolaryngology/Head & Neck Surgery, Zucker School of Medicine, Hofstra University, New York, NY 11040, USA.

Department of Otolaryngology/Head & Neck Surgery, Montefiore Medical Center, New York, NY 10467, USA.

出版信息

Cancers (Basel). 2024 Dec 24;17(1):4. doi: 10.3390/cancers17010004.


DOI:10.3390/cancers17010004
PMID:39796633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11718787/
Abstract

Squamous cell carcinoma is the most common malignancy affecting the sinonasal tract. Local recurrence is the main pattern of treatment failure, affecting nearly half of patients treated for primary sinonasal squamous cell carcinoma (SNSCC). Due to disease rarity and heterogeneity of practices, there are limited guidelines for how to diagnose and care for these patients. This paper reviews current evidence regarding etiology, pathophysiology, diagnosis, prognostic factors, and treatment modalities of recurrent SNSCC (rSNSCC). Currently, salvage surgery offers the only durable approach for eligible patients. These resections often require robust reconstructive options due to prior surgery or radiation. Chemoradiation is offered as an adjuvant or palliative approach when surgery is not a feasible option. Emerging options such as immunotherapy and particle therapy remain an area of ongoing investigation.

摘要

鳞状细胞癌是影响鼻窦区域最常见的恶性肿瘤。局部复发是治疗失败的主要模式,几乎影响了一半接受原发性鼻窦鳞状细胞癌(SNSCC)治疗的患者。由于该疾病罕见且治疗方法存在异质性,关于如何诊断和治疗这些患者的指南有限。本文综述了复发性鼻窦鳞状细胞癌(rSNSCC)的病因、病理生理学、诊断、预后因素及治疗方式的现有证据。目前,挽救性手术为符合条件的患者提供了唯一持久的治疗方法。由于先前的手术或放疗,这些切除术通常需要强大的重建方案。当手术不可行时,放化疗可作为辅助或姑息治疗方法。免疫疗法和粒子疗法等新兴治疗方法仍是正在进行研究的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251b/11718787/b441c20d90ec/cancers-17-00004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251b/11718787/b441c20d90ec/cancers-17-00004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251b/11718787/b441c20d90ec/cancers-17-00004-g001.jpg

相似文献

[1]
Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances.

Cancers (Basel). 2024-12-24

[2]
Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence.

Cancers (Basel). 2021-6-7

[3]
Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract: A systematic meta-analysis with PRISMA guidelines.

Medicine (Baltimore). 2017-3

[4]
The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma.

Auris Nasus Larynx. 2021-2

[5]
Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results.

Arch Otolaryngol Head Neck Surg. 2009-12

[6]
Complete remission in a patient with sinonasal squamous cell carcinoma receiving neoadjuvant tislelizumab plus chemotherapy: a case report.

Front Immunol. 2024

[7]
Prevalence and association of Epstein-Barr virus infection with sinonasal inverted papilloma and sinonasal squamous cell carcinoma in the northeastern Thai population.

Infect Agent Cancer. 2020-6-24

[8]
The Role of Salvage in the Management of Patients with Sinonasal Squamous Cell Carcinoma.

Biomedicines. 2022-5-28

[9]
Impact of facility volume on survival in primary endoscopic surgery for sinonasal squamous cell carcinoma.

Am J Otolaryngol. 2024

[10]
Circulating Tumor DNA Testing for Detection and Surveillance of Sinonasal HPV-Associated Cancers.

J Neurol Surg Rep. 2025-4-25

本文引用的文献

[1]
Comparison of surveillance modalities in the surveillance of sinonasal squamous cell carcinoma recurrence: A multi-institutional study.

Int Forum Allergy Rhinol. 2025-4

[2]
Complete remission in a patient with sinonasal squamous cell carcinoma receiving neoadjuvant tislelizumab plus chemotherapy: a case report.

Front Immunol. 2024

[3]
Longer-term surveillance imaging and endoscopy critical for majority of patients in detection of sinonasal malignancy recurrence.

Int Forum Allergy Rhinol. 2024-11

[4]
Patterns of failure after salvage head and neck surgery.

Oral Oncol. 2024-10

[5]
Re-irradiation versus systemic therapy for the management of local-regionally recurrent head and neck cancer.

Radiother Oncol. 2024-7

[6]
Radiotherapy Results in Locally Advanced Sinonasal Cancer: Turkish Society for Radiation Oncology, Head and Neck Study Group 01-005.

Am J Clin Oncol. 2024-6-1

[7]
What is the rate of occult nodal metastasis in squamous cell carcinomas of the sinonasal tract? A systematic review.

Eur Arch Otorhinolaryngol. 2024-7

[8]
Perineural invasion is a poor prognostic factor for sinonasal squamous cell carcinoma.

Oral Oncol. 2024-3

[9]
The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment.

Front Immunol. 2023

[10]
Patterns of recurrence in head and neck squamous cell carcinoma to inform personalized surveillance protocols.

Cancer. 2023-9-15

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