Nakamura M, Koketsu K
Arch Int Pharmacodyn Ther. 1978 Apr;232(2):291-301.
The actions of g-strophanthin, adrenaline and acetylcholine on the action potential of bullfrog ventricular muscle were studied in the Na+ -free Li+ solution, in order to examine if these actions are associated with the change of active Na+ transport. The action of g-strophanthin on the action potential, being observed in the Ringer solution, completely disappeared in the Na+-free Li+ solution. On the other hand, the actions of adrenaline and acetylcholine remained unchanged in the Na+ -free Li+ solution, except the hyperpolarizing action of adrenaline on the resting membrane. These results suggest that changes of the action potential by g-strophanthin are secondary events caused by the change of active Na+ transport, whereas those by adrenaline and acetylcholine are primary events due to the change of membrane permeability.
在无钠锂溶液中研究了毒毛花苷、肾上腺素和乙酰胆碱对牛蛙心室肌动作电位的作用，以检验这些作用是否与主动钠转运的变化有关。毒毛花苷对动作电位的作用在任氏液中可观察到，但在无钠锂溶液中则完全消失。另一方面，除了肾上腺素对静息膜的超极化作用外，肾上腺素和乙酰胆碱在无钠锂溶液中的作用保持不变。这些结果表明，毒毛花苷引起的动作电位变化是由主动钠转运变化引起的继发事件，而肾上腺素和乙酰胆碱引起的动作电位变化是由膜通透性变化导致的原发事件。
