CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
QOPNA-Química Orgânica, Produtos Naturais e Agroalimentares, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Int J Mol Sci. 2019 Feb 21;20(4):940. doi: 10.3390/ijms20040940.
Worldwide, foodborne diseases are a growing public health problem. Among the infectious bacteria, non-typhoidal serovars (NTS) are the major cause of hospitalization and death, and the emergence and spread of their antibiotic-resistance is becoming a worldwide health issue. This, coupled with the restrictions of antibiotics use in agriculture and animal production, calls for alternative approaches to solve this problem. Plant-derived aqueous extracts compounds could provide novel straightforward approaches to control pathogenic bacteria. This review discusses the antimicrobial activity of aqueous plant extracts against serovars, the possible mechanisms of action involved, which components/structures might be responsible for such activity, and the current challenges for the use of these extracts/components in infection management and their application perspectives.
在全球范围内，食源性疾病是一个日益严重的公共卫生问题。在传染性细菌中，非伤寒血清型（NTS）是导致住院和死亡的主要原因，其抗生素耐药性的出现和传播正成为一个全球性的健康问题。再加上农业和动物生产中抗生素使用的限制，这就需要寻找替代方法来解决这个问题。植物源水提物化合物可能为控制病原菌提供新颖的直接方法。本文讨论了水提植物提取物对血清型的抗菌活性、涉及的可能作用机制、可能负责这种活性的成分/结构，以及这些提取物/成分在感染管理中的应用所面临的挑战及其应用前景。
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