Rempe Caroline S, Burris Kellie P, Lenaghan Scott C, Stewart C Neal
College of Arts and Sciences, Graduate School of Genome Science and Technology, University of Tennessee Knoxville, TN, USA.
Department of Food Science, University of TennesseeKnoxville, TN, USA; Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State UniversityRaleigh, NC, USA.
Front Microbiol. 2017 Mar 16;8:422. doi: 10.3389/fmicb.2017.00422. eCollection 2017.
Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult and is uncommon in assessments of plant phenolic compounds. With systems biology approaches, though, antibacterial mechanisms can be assessed without the bias of target-directed bioassays to enable the discovery of novel mechanism(s) of action against drug resistant microorganisms. This review article summarizes the current knowledge of antibacterial mechanisms of action of plant phenolic compounds and discusses relevant methodology.
细菌病原体的耐药性是一个日益严重的问题，可通过发现具有新型抗菌活性机制的化合物来解决。天然产物，包括植物酚类化合物，是具有多样化学结构的一个来源，这些结构可以通过新型机制抑制细菌。然而，评估新型抗菌作用机制可能很困难，并且在植物酚类化合物的评估中并不常见。不过，借助系统生物学方法，可以在没有靶向生物测定偏差的情况下评估抗菌机制，从而发现针对耐药微生物的新型作用机制。这篇综述文章总结了目前关于植物酚类化合物抗菌作用机制的知识，并讨论了相关方法。
