丁酸和二甲基亚砜对小鼠黑色素瘤的生长抑制作用

Growth inhibition of murine melanoma by butyric acid and dimethylsulfoxide.

作者信息

Nordenberg J, Wasserman L, Beery E, Aloni D, Malik H, Stenzel K H, Novogrodsky A

出版信息

Exp Cell Res. 1986 Jan;162(1):77-85. doi: 10.1016/0014-4827(86)90427-1.

Abstract

Treatment of B16-F10 melanoma cells with dimethylsulfoxide (DMSO) or butyric acid (BA) inhibits cell growth and delays tumor appearance in syngeneic mice. Both agents induce morphological changes in these cells. Treatment of melanoma cells with DMSO results in a marked increase in tyrosinase activity and melanin content. BA, on the other hand, does not increase melanin content and decreases tyrosinase activity. The data show that there are marked differences in the effect of DMSO and BA on melanin biosynthesis, whereas both agents inhibit cell growth and cause a delay in tumor appearance. These findings indicate that decreased proliferation of melanoma cells and induction of melanin biosynthesis are not necessarily associated phenomena.

摘要

用二甲基亚砜（DMSO）或丁酸（BA）处理B16-F10黑色素瘤细胞可抑制细胞生长，并延缓同基因小鼠体内肿瘤的出现。两种试剂都会诱导这些细胞发生形态变化。用DMSO处理黑色素瘤细胞会导致酪氨酸酶活性和黑色素含量显著增加。另一方面，BA不会增加黑色素含量，反而会降低酪氨酸酶活性。数据表明，DMSO和BA对黑色素生物合成的影响存在显著差异，而两种试剂均能抑制细胞生长并延缓肿瘤出现。这些发现表明，黑色素瘤细胞增殖的减少和黑色素生物合成的诱导不一定是相关联的现象。