NatMEG, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Section of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Sci Rep. 2019 Feb 22;9(1):2604. doi: 10.1038/s41598-019-39204-3.
Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8-30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.
运动症状是帕金森病（PD）诊断的决定性特征。运动功能的一个关键组成部分是传入本体感觉反馈的整合。先前的研究表明，PD 患者的运动相关皮质振荡活动异常，但 PD 患者本体感觉传入对异常振荡活动的作用尚未阐明。我们研究了 PD 患者、ON/OFF 左旋多巴药物与健康对照组（HC）在处理本体感觉刺激时的 mu/beta 波段（8-30 Hz）皮质振荡。我们使用了一种本体感觉刺激器，它可以产生精确控制的食指被动运动，并使用脑磁图测量了本体感觉刺激后的诱导皮质振荡反应。PD 患者和 HC 在被动运动期间均表现出典型的 beta 带去同步化。然而，与 HC 相比，PD 患者的被动运动后几乎没有出现 beta 反弹。此外，我们发现 PD 患者 ON 和 OFF 左旋多巴药物之间的 beta 反弹衰减程度没有差异。结果表明，PD 患者的本体感觉传入皮质处理存在与疾病相关的恶化。
