Nichols J, Straub K D, Abernathy S
Biochim Biophys Acta. 1978 Aug 4;511(2):251-8. doi: 10.1016/0005-2736(78)90318-8.
Sanguinarine, a benzophenanthridine alkaloid, causes a initial stimulation of frog skin short circuit current Isc when present in the mucosal bathing medium at 10(-4) M. The stimulation is accompanied by an increase in spontaneous potential difference (PD) and increase in D.C. resistance. No effects are seen with sanguinarine in the serosal bathing medium. The initial stimulation is followed by a decrease in Isc and PD, but a continued increase in resistance. In skins whose initial spontaneous PD is high, no initial stimulation in Isc and PD is seen; however, clamping these skins to a lower potential does not alter their initial inhibitory response to sanguinarine. Likewise, clamping the lower potential skins to higher potential does not alter their initial stimulatory response. Sanguinarine seems to be acting on the permeability barriers at the outer surface of the frog skin.
血根碱是一种苯并菲啶生物碱，当以10⁻⁴M的浓度存在于黏膜浴液介质中时，会引起蛙皮短路电流（Isc）的初始刺激。这种刺激伴随着自发电位差（PD）的增加和直流电阻的增加。在浆膜浴液介质中加入血根碱则没有效果。初始刺激之后，Isc和PD会下降，但电阻会持续增加。对于初始自发电位差较高的皮肤，未观察到Isc和PD的初始刺激；然而，将这些皮肤钳制在较低电位并不会改变它们对血根碱的初始抑制反应。同样，将低电位皮肤钳制在较高电位也不会改变它们的初始刺激反应。血根碱似乎作用于蛙皮外表面的通透性屏障。
