Ricklefs Franz L, Fritzsche Friederike, Winkler Beate, Meissner Barbara, Dührsen Lasse, Westphal Manfred, Rutkowski Stefan, Martens Tobias, Schüller Ulrich
Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Childs Nerv Syst. 2019 Jun;35(6):1029-1033. doi: 10.1007/s00381-019-04086-3. Epub 2019 Feb 22.
Recent studies on medulloblastomas (MB) suggest that a large fraction of tumors appearing as late recurrence turn out to be secondary malignancies, e.g., malignant gliomas, after thorough molecular investigation.
Here, we report of a patient with a group 4 MB that developed a distant recurrence after more than 18 years. The recurrent tumor was confirmed by histology and genome-wide DNA methylation profiling.
Our case not only illustrates the potential of very late recurrences after seemingly cured group 4 MB, but also illustrates that detailed molecular analyses are indispensable in patients with a history of a previous malignancy.
近期关于髓母细胞瘤（MB）的研究表明，经过全面分子检测，很大一部分表现为晚期复发的肿瘤最终被证实为继发性恶性肿瘤，如恶性胶质瘤。
在此，我们报告1例4组MB患者，其在超过18年后出现远处复发。复发性肿瘤经组织学及全基因组DNA甲基化分析得以确诊。
我们的病例不仅表明看似治愈的4组MB有极晚期复发的可能，还表明对于有既往恶性肿瘤病史的患者，详细的分子分析必不可少。
