内毒素对氧中毒的保护作用及其被乙酰水杨酸逆转的情况。

Endotoxin protection against oxygen toxicity and its reversal by acetylsalicylic acid.

作者信息

Klein J, Trouwborst A, Salt P J

出版信息

Crit Care Med. 1986 Jan;14(1):32-3. doi: 10.1097/00003246-198601000-00008.

DOI:10.1097/00003246-198601000-00008

Abstract

This study investigated the involvement of substances derived from arachidonic acid in the mechanism of endotoxin's protective action against pulmonary oxygen toxicity. Eighty-three percent of rats treated with a small dose of endotoxin (1 mg/kg) survived exposure to over 95% oxygen for 7 days. In contrast, all control rats exposed to the same oxygen concentration died within 3 days. When the endotoxin-treated rats were also treated with the soluble lysine salt of acetylsalicylic acid (100 mg/kg), 7-day survival decreased to 25%. This suggests that prostaglandin metabolism may play an important role in the protective action of endotoxin during hyperoxia.

摘要

本研究调查了花生四烯酸衍生物质在内毒素对肺氧中毒保护作用机制中的参与情况。用小剂量内毒素（1毫克/千克）治疗的大鼠中，83%在暴露于超过95%氧气环境7天后存活下来。相比之下，暴露于相同氧浓度的所有对照大鼠在3天内死亡。当用乙酰水杨酸的可溶性赖氨酸盐（100毫克/千克）治疗内毒素处理的大鼠时，7天存活率降至25%。这表明前列腺素代谢可能在高氧期间内毒素的保护作用中起重要作用。