Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Neurosciences & Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Canada.
Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Neurosciences & Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Canada; Department of Psychology, University of Toronto, Toronto, Canada.
Neurosci Lett. 2019 May 14;701:112-118. doi: 10.1016/j.neulet.2019.02.021. Epub 2019 Feb 21.
Disruptions in fronto-limbic circuitry have been reported in adults with borderline personality disorder (BPD), yet it is unknown whether dynamic functional neurophysiology is similarly altered in adolescents with high levels of BPD traits. Using magnetoencephalography (MEG) and an implicit perception of emotional faces task, this study investigated task-dependent functional connectivity of eight a priori regions of interest implicated in emotional processing, in 16 females with and without BPD traits. An underconnected network of areas was observed in the BPD-trait group during implicit angry face perception - an effect absent for happy faces. This hyposynchronous fronto-limbic circuit included connections among bilateral amygdalae and bilateral anterior cingulate cortex (ACC), and additional regions implicated in emotion processing. These preliminary, novel results extend existing findings in adults with a diagnosis of BPD, and suggest that disrupted neurophysiological circuitry underlies maladaptive perception of threatening emotional expressions in others, manifests around a key milestone in neurodevelopement, and might contribute to the emotional dysregulation and difficulties with interpersonal relationships commonly found in adolescents high in BPD traits.
边缘型人格障碍（BPD）患者的额 - 边缘回路存在中断，但其高 BPD 特质青少年的动态功能神经生理学是否也发生了类似的改变尚不清楚。本研究采用脑磁图（MEG）和情绪面孔的内隐知觉任务，对 16 名有和无 BPD 特质的女性进行了 8 个与情绪处理相关的先验感兴趣区的任务相关功能连接研究。在对愤怒面孔的内隐知觉中，BPD 特质组观察到一个连接不足的额 - 边缘回路，对快乐面孔则没有这种效应。这种低同步的额 - 边缘回路包括双侧杏仁核和双侧前扣带皮层（ACC）之间的连接，以及与情绪处理相关的其他区域。这些初步的、新颖的结果扩展了具有 BPD 诊断的成年患者的现有发现，并表明神经生理回路的中断是导致对他人威胁性情绪表达的适应不良感知的基础，在神经发育的一个关键里程碑出现，可能导致 BPD 特质较高的青少年中常见的情绪失调和人际关系困难。
