Suppr超能文献

用于癌症硼中子俘获治疗的 o--carborane 的脂质体制剂。

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer.

机构信息

School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.

School of Life Science, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston-upon-Thames, Surrey KT1 2EE, UK.

出版信息

Biophys Chem. 2019 Apr;247:25-33. doi: 10.1016/j.bpc.2019.01.003. Epub 2019 Feb 15.

Abstract

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80-100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

摘要

基于脂质体作为硼中子俘获治疗(BNCT)用硼化试剂的便捷载体的承诺,本文报道了一种制备和表征稳定的负载 o-卡硼烷的二棕榈酰基磷脂酰胆碱(DPPC)或 1,2-二硬脂酰基-sn-甘油-3-磷酸胆碱(DSPC)脂质体(约 80-100nm)的方法。初步的药物特性研究表明 DPPC 和 DSPC 脂质体膜在血清和 PBS 中具有完整性,并且还表明这些负载 o-卡硼烷的脂质体是进一步评估的候选载体,以期在 BNCT 中得到应用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验