School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.
School of Life Science, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston-upon-Thames, Surrey KT1 2EE, UK.
Biophys Chem. 2019 Apr;247:25-33. doi: 10.1016/j.bpc.2019.01.003. Epub 2019 Feb 15.
Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80-100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
基于脂质体作为硼中子俘获治疗(BNCT)用硼化试剂的便捷载体的承诺,本文报道了一种制备和表征稳定的负载 o-卡硼烷的二棕榈酰基磷脂酰胆碱(DPPC)或 1,2-二硬脂酰基-sn-甘油-3-磷酸胆碱(DSPC)脂质体(约 80-100nm)的方法。初步的药物特性研究表明 DPPC 和 DSPC 脂质体膜在血清和 PBS 中具有完整性,并且还表明这些负载 o-卡硼烷的脂质体是进一步评估的候选载体,以期在 BNCT 中得到应用。