含氟化亚锡牙膏在不同口腔微环境下的抗菌效果。

Antimicrobial effects of a stannous fluoride toothpaste in distinct oral microenvironments.

出版信息

J Am Dent Assoc. 2019 Apr;150(4S):S14-S24. doi: 10.1016/j.adaj.2019.01.007.

DOI:10.1016/j.adaj.2019.01.007

Abstract

BACKGROUND

Clinical research has shown a relationship between microbial accumulations and oral diseases such as gingivitis and caries. The mouth harbors large densities of bacteria in distinct oral microenvironments, that is, dental plaque on teeth, saliva, and soft tissues such as the tongue, cheek, and gingiva. In this home-use study, the authors compared the effects of brushing with a newly formulated stannous fluoride toothpaste and a sodium monofluorophosphate dentifrice on bacteria of distinct oral microenvironments.

METHODS

Adult participants completed a washout phase before baseline sampling of dental plaque, saliva, and scrapings from tongue, cheek, and gingiva, which were used for microbiological analysis. Treatments were randomly assigned: test (62 participants) and control (67 participants) for twice-daily toothbrushing over 8 weeks. After 4 weeks and 8 weeks, posttreatment samples 12 hours after brushing were collected for analysis. At these posttreatment visits, participants brushed in the dental clinic, and an additional sample was collected 4 hours later for microbiological analysis.

RESULTS

Relative to the control, 12 hours after brushing, the test toothpaste showed greater reductions of bacteria (ranging from 14% to 27%) at the 4-week evaluation, which increased to 27% to 41% after 8 weeks of brushing. Correspondingly, 4 hours after brushing with the test toothpaste at the 4-week evaluation, there were greater reductions of bacteria in the range of 22% to 59%, which increased to a range of 33% to 61% at the 8-week assessment for participants completing the study.

CONCLUSIONS

The stannous fluoride toothpaste provided bacterial reductions in all oral microenvironments 12 hours after brushing. In addition, the authors observed microbial reductions 4 hours after brushing, which increased after extended use.

PRACTICAL IMPLICATIONS

The results are appropriate for oral hygiene recommendations by dental professionals.

摘要

背景

临床研究表明，微生物的积累与牙龈炎和龋齿等口腔疾病之间存在关联。口腔中存在大量不同的口腔微环境中的细菌，即牙齿上的牙菌斑、唾液和舌、颊、牙龈等软组织。在这项家庭使用研究中，作者比较了使用新配方的氟化亚锡牙膏和单氟磷酸钠牙膏刷牙对不同口腔微环境中的细菌的影响。

方法

成年参与者在基线采样前完成了一个冲洗阶段，采集了牙菌斑、唾液和舌、颊、牙龈的刮片样本，用于微生物分析。治疗方法为随机分配：试验组（62 名参与者）和对照组（67 名参与者），每天刷牙两次，共 8 周。4 周和 8 周后，刷牙后 12 小时收集治疗后样本进行分析。在这些治疗后就诊时，参与者在牙科诊所刷牙，并在 4 小时后采集额外样本进行微生物分析。

结果

与对照组相比，试验牙膏在第 4 周评估时，刷牙后 12 小时，对细菌的减少幅度更大（范围为 14%至 27%），8 周后增加到 27%至 41%。相应地，在第 4 周评估时，用试验牙膏刷牙 4 小时后，细菌减少范围在 22%至 59%之间，在完成研究的参与者中，8 周评估时增加到 33%至 61%。