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用针对小鼠干扰素γ的单克隆抗体中和成纤维细胞和巨噬细胞的淋巴因子介导的抗立克次氏体活性。

Neutralization of lymphokine-mediated antirickettsial activity of fibroblasts and macrophages with monoclonal antibody specific for murine interferon gamma.

作者信息

Jerrells T R, Turco J, Winkler H H, Spitalny G L

出版信息

Infect Immun. 1986 Jan;51(1):355-9. doi: 10.1128/iai.51.1.355-359.1986.

DOI:10.1128/iai.51.1.355-359.1986
PMID:3079735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261111/
Abstract

Lymphokine-mediated inhibition of Rickettsia prowazekii multiplication in L929 fibroblasts was eliminated by treatment of the lymphokine with a monoclonal antibody specific for interferon-gamma. Soluble monoclonal antibody and antibody conjugated to Sepharose beads were equally effective. Macrophage activation to limit the multiplication of Rickettsia conorii was eliminated with antibody-conjugated beads; however, neutralization of the ability to activate macrophages with soluble antibody was not complete and required more antibody than did neutralization of antiviral activity.

摘要

用针对γ干扰素的单克隆抗体处理淋巴因子后，消除了淋巴因子介导的对普氏立克次体在L929成纤维细胞中增殖的抑制作用。可溶性单克隆抗体和与琼脂糖珠偶联的抗体效果相同。用与珠偶联的抗体消除了巨噬细胞激活以限制康氏立克次体增殖的作用；然而，用可溶性抗体中和激活巨噬细胞的能力并不完全，且比中和抗病毒活性需要更多的抗体。

相似文献

1
Neutralization of lymphokine-mediated antirickettsial activity of fibroblasts and macrophages with monoclonal antibody specific for murine interferon gamma.用针对小鼠干扰素γ的单克隆抗体中和成纤维细胞和巨噬细胞的淋巴因子介导的抗立克次氏体活性。
Infect Immun. 1986 Jan;51(1):355-9. doi: 10.1128/iai.51.1.355-359.1986.
2
Comparison of the properties of antirickettsial activity and interferon in mouse lymphokines.小鼠淋巴因子中抗立克次氏体活性与干扰素特性的比较。
Infect Immun. 1983 Oct;42(1):27-32. doi: 10.1128/iai.42.1.27-32.1983.
3
Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.克隆的小鼠干扰素-γ可抑制普氏立克次体在培养的小鼠成纤维细胞中的生长。
J Exp Med. 1983 Dec 1;158(6):2159-64. doi: 10.1084/jem.158.6.2159.
4
Gamma-interferon-induced inhibition of the growth of Rickettsia prowazekii in fibroblasts cannot be explained by the degradation of tryptophan or other amino acids.γ-干扰素诱导的对普氏立克次体在成纤维细胞中生长的抑制作用，无法用色氨酸或其他氨基酸的降解来解释。
Infect Immun. 1986 Jul;53(1):38-46. doi: 10.1128/iai.53.1.38-46.1986.
5
Interferonlike factors from antigen- and mitogen-stimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii. Infected human endothelial cells, fibroblasts, and macrophages.来自抗原和丝裂原刺激的人白细胞的类干扰素因子，对普氏立克次体具有抗立克次体和细胞溶解作用。感染的人内皮细胞、成纤维细胞和巨噬细胞。
J Exp Med. 1983 Jun 1;157(6):1780-93. doi: 10.1084/jem.157.6.1780.
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Nitric oxide-mediated inhibition of the ability of Rickettsia prowazekii to infect mouse fibroblasts and mouse macrophagelike cells.一氧化氮介导对普氏立克次体感染小鼠成纤维细胞和小鼠巨噬样细胞能力的抑制。
Infect Immun. 1998 Feb;66(2):558-66. doi: 10.1128/IAI.66.2.558-566.1998.
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Interferon-gamma- and rickettsia-induced killing of macrophage-like cells is inhibited by anti-rickettsial antibodies and does not require the respiratory burst.抗立克次体抗体可抑制干扰素-γ和立克次体诱导的巨噬细胞样细胞杀伤，且该过程不需要呼吸爆发。
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Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines.淋巴因子对培养的成纤维细胞中普氏立克次体生长的抑制作用。
J Exp Med. 1983 Mar 1;157(3):974-86. doi: 10.1084/jem.157.3.974.
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Isolation of Rickettsia prowazekii with reduced sensitivity to gamma interferon.对γ干扰素敏感性降低的普氏立克次体的分离
Infect Immun. 1989 Jun;57(6):1765-72. doi: 10.1128/iai.57.6.1765-1772.1989.
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Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.抗小鼠γ干扰素单克隆抗体可抑制淋巴因子诱导的抗病毒及巨噬细胞杀肿瘤活性。
J Exp Med. 1984 May 1;159(5):1560-5. doi: 10.1084/jem.159.5.1560.

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Lack of effect of dexamethasone on growth of Orientia tsutsugamushi Gilliam in mouse L929 cells.地塞米松对恙虫东方体在小鼠 L929 细胞中生长的影响。
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Infect Immun. 1998 May;66(5):1855-60. doi: 10.1128/IAI.66.5.1855-1860.1998.
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Murine T-cell response to native and recombinant protein antigens of Rickettsia tsutsugamushi.小鼠对恙虫病东方体天然和重组蛋白抗原的T细胞应答。
Infect Immun. 1993 May;61(5):1674-81. doi: 10.1128/iai.61.5.1674-1681.1993.
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Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide.γ干扰素和肿瘤坏死因子α通过诱导一氧化氮的合成发挥其抗立克次体作用。
Am J Pathol. 1993 Oct;143(4):1016-23.
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Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease.感染康氏立克次体的小鼠内皮细胞中γ干扰素和肿瘤坏死因子α的耗竭：杀立克次体一氧化氮产生受损导致致命的、严重的立克次体病。
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Synthesis of DNA, rRNA, and protein by Rickettsia prowazekii growing in untreated or gamma interferon-treated mouse L929 cells.在未处理或经γ干扰素处理的小鼠L929细胞中生长的普氏立克次体对DNA、rRNA和蛋白质的合成。
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本文引用的文献

1
Immune responses to Rickettsia akari infection in congenitally athymic nude mice.先天性无胸腺裸鼠对小蛛立克次体感染的免疫反应。
Infect Immun. 1980 May;28(2):310-3. doi: 10.1128/iai.28.2.310-313.1980.
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Host defenses in experimental scrub typhus: delayed-type hypersensitivity responses of inbred mice.实验性恙虫病中的宿主防御：近交系小鼠的迟发型超敏反应
Infect Immun. 1982 Jan;35(1):117-23. doi: 10.1128/iai.35.1.117-123.1982.
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The biology of rickettsiae.立克次氏体生物学
Annu Rev Microbiol. 1982;36:345-70. doi: 10.1146/annurev.mi.36.100182.002021.
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Effect of mouse lymphokines and cloned mouse interferon-gamma on the interaction of Rickettsia prowazekii with mouse macrophage-like RAW264.7 cells.小鼠淋巴因子和克隆的小鼠γ干扰素对普氏立克次体与小鼠巨噬细胞样RAW264.7细胞相互作用的影响。
Infect Immun. 1984 Aug;45(2):303-8. doi: 10.1128/iai.45.2.303-308.1984.
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Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.抗小鼠γ干扰素单克隆抗体可抑制淋巴因子诱导的抗病毒及巨噬细胞杀肿瘤活性。
J Exp Med. 1984 May 1;159(5):1560-5. doi: 10.1084/jem.159.5.1560.
6
Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.克隆的小鼠干扰素-γ可抑制普氏立克次体在培养的小鼠成纤维细胞中的生长。
J Exp Med. 1983 Dec 1;158(6):2159-64. doi: 10.1084/jem.158.6.2159.
7
Comparison of the properties of antirickettsial activity and interferon in mouse lymphokines.小鼠淋巴因子中抗立克次氏体活性与干扰素特性的比较。
Infect Immun. 1983 Oct;42(1):27-32. doi: 10.1128/iai.42.1.27-32.1983.
8
Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines.淋巴因子对培养的成纤维细胞中普氏立克次体生长的抑制作用。
J Exp Med. 1983 Mar 1;157(3):974-86. doi: 10.1084/jem.157.3.974.
9
Activation of macrophages to kill rickettsiae and Leishmania: dissociation of intracellular microbicidal activities and extracellular destruction of neoplastic and helminth targets.巨噬细胞激活以杀伤立克次体和利什曼原虫：细胞内杀菌活性与肿瘤及蠕虫靶标的细胞外破坏的分离
Contemp Top Immunobiol. 1984;13:147-70. doi: 10.1007/978-1-4757-1445-6_8.
10
Production of gamma interferon in mice immune to Rickettsia tsutsugamushi.对恙虫病立克次氏体免疫的小鼠中γ干扰素的产生。
Infect Immun. 1984 Jan;43(1):59-65. doi: 10.1128/iai.43.1.59-65.1984.