Hunt J S, Wood G W
J Immunol. 1986 Jan;136(2):364-7.
In contrast to other human nucleated cells, amnionic epithelial cells do not normally express class I HLA antigens. It is not known whether the failure of display of those antigens occurs because genes for HLA expression are deleted or are defective, or if gene expression is repressed. The results of the present study demonstrate that amnionic epithelial cells exposed to IFN-gamma express levels of class I HLA antigens and beta 2-microglobulin that are readily detectable in immunoperoxidase and immunofluorescence stains. The findings suggest that failure of transcription may be responsible for failure of normal expression of class I HLA antigens and beta 2-microglobulin by cells of the amnion membrane. Class II antigens, which are normally expressed by very few cell types, were not expressed by amnion cells under any test conditions.
与其他人类有核细胞不同，羊膜上皮细胞通常不表达I类HLA抗原。尚不清楚这些抗原的不表达是因为HLA表达基因被删除或有缺陷，还是基因表达受到抑制。本研究结果表明，暴露于γ干扰素的羊膜上皮细胞表达的I类HLA抗原和β2-微球蛋白水平，在免疫过氧化物酶和免疫荧光染色中易于检测到。这些发现表明，转录失败可能是羊膜细胞正常表达I类HLA抗原和β2-微球蛋白失败的原因。II类抗原通常仅由极少数细胞类型表达，在任何测试条件下羊膜细胞均不表达。
