Stickel S, Eickhoff S, Goecke T W, Schneider F, Quinete N S, Lang J, Habel U, Chechko N
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, Uniklinik RWTH Aachen, Aachen, Germany; Institute of Neuroscience and Medicine: JARA-Institute Brain Structure Function Relationship (INM 10), Research Center Jülich, Jülich, Germany.
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
Biol Psychol. 2019 Apr;143:53-61. doi: 10.1016/j.biopsycho.2019.02.008. Epub 2019 Feb 21.
Prolonged stress affects the central nervous system, rendering individuals vulnerable to a wide range of mental health disorders. 76 healthy postpartum mothers were studied by means of functional magnetic resonance imaging within 6 days of childbirth. The subjects were required to perform the emotional Stroop task involving happy and anxious word-face combinations. Hair samples were collected to determine cumulative hair cortisol concentration (HCC) in the third trimester. HCC was found to be negatively correlated with the recruitment of the dorsal anterior cingulate cortex (ACC) and the midcingulate cortex (MCC). In response to the emotional interference of only anxious target faces, a negative correlation was seen between HCC and the bilateral orbitofrontal cortex, extending to the rostral ACC and the MCC. Women with lower HCC recruited brain areas relevant to emotional cognitive control, indicating that lower HCC helps preserve conflict monitoring and resolution capacities and thus benefits mental health in pregnancy.
长期压力会影响中枢神经系统，使个体易患多种心理健康障碍。研究人员在76名健康的产后母亲分娩后6天内，通过功能磁共振成像对她们进行了研究。受试者被要求执行涉及快乐和焦虑词汇-面孔组合的情绪Stroop任务。收集头发样本以确定孕晚期的累积头发皮质醇浓度（HCC）。研究发现，HCC与背侧前扣带回皮质（ACC）和扣带中部皮质（MCC）的激活呈负相关。仅在面对焦虑目标面孔的情绪干扰时，HCC与双侧眶额皮质呈负相关，并延伸至喙部ACC和MCC。HCC较低的女性会激活与情绪认知控制相关的脑区，这表明较低的HCC有助于维持冲突监测和解决能力，从而对孕期心理健康有益。
