Institut Galien Paris-Sud, Université Paris-Sud, CNRS, Université Paris Saclay, Châtenay-Malabry, France.
Adv Drug Deliv Rev. 2019 Nov-Dec;151-152:233-244. doi: 10.1016/j.addr.2019.02.005. Epub 2019 Feb 21.
Adenosine is a fascinating compound, crucial in many biochemical processes: this ubiquitous nucleoside serves as an essential building block of RNA, is also a component of ATP and regulates numerous pathophysiological mechanisms via binding to four extracellular receptors. Due to its hydrophilic nature, it belongs to a different world than lipids, and has no affinity for them. Since the 1970's, however, new discoveries have emerged and prompted the scientific community to associate adenosine with the lipid family, especially via liposomal preparations and bioconjugation. This seems to be an arranged marriage, but could it turn into a true love match? This review considered all types of unions established between adenosine and lipids. Even though exciting supramolecular structures were observed with adenosine-lipid conjugates, as well as with liposomal preparations which resulted in promising pre-clinical results, the translation of these technologies to the clinic is still limited.
腺苷是一种引人入胜的化合物，在许多生化过程中都至关重要：这种普遍存在的核苷既是 RNA 的重要组成部分，也是 ATP 的组成部分，并通过与四个细胞外受体结合来调节许多病理生理机制。由于其亲水性，它与脂质属于不同的世界，并且与脂质没有亲和力。然而，自 20 世纪 70 年代以来，新的发现出现了，并促使科学界将腺苷与脂质家族联系起来，特别是通过脂质体制剂和生物缀合。这似乎是一场包办婚姻，但它能变成真爱吗？这篇综述考虑了腺苷与脂质之间建立的所有类型的结合。尽管与腺苷脂质缀合物以及脂质体制剂观察到了令人兴奋的超分子结构，这些制剂在临床前研究中取得了有希望的结果，但这些技术向临床的转化仍然受到限制。
