Solopova I A, Zhvansky D S, Selionov V A, Ivanenko Y
Laboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Moscow, Russia.
Laboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Moscow, Russia.
Hum Mov Sci. 2019 Apr;64:230-239. doi: 10.1016/j.humov.2019.02.008. Epub 2019 Feb 21.
In recent years, neuromodulation of the cervical spinal circuitry has become an area of interest for investigating rhythmogenesis of the human spinal cord and interaction between cervical and lumbosacral circuitries, given the involvement of rhythmic arm muscle activity in many locomotor tasks. We have previously shown that arm muscle vibrostimulation can elicit non-voluntary upper limb oscillations in unloading body conditions. Here we investigated the excitability of the cervical spinal circuitry by applying different peripheral and central stimuli in healthy humans. The rationale for applying combined stimuli is that the efficiency of only one stimulus is generally limited. We found that low-intensity electrical stimulation of the superficial arm median nerve can evoke rhythmic arm movements. Furthermore, the movements were enhanced by additional peripheral stimuli (e.g., arm muscle vibration, head turns or passive rhythmic leg movements). Finally, low-frequency transcranial magnetic stimulation of the motor cortex significantly facilitated rhythmogenesis. The findings are discussed in the general framework of a brain-spinal interface for developing adaptive central pattern generator-modulating therapies.
近年来，鉴于有节奏的手臂肌肉活动参与了许多运动任务，颈脊髓回路的神经调节已成为研究人类脊髓节律发生以及颈腰回路之间相互作用的一个有趣领域。我们之前已经表明，在身体卸载状态下，手臂肌肉振动刺激可引发非自愿性上肢振荡。在此，我们通过对健康受试者施加不同的外周和中枢刺激，研究了颈脊髓回路的兴奋性。应用联合刺激的基本原理是，单一刺激的效果通常是有限的。我们发现，对臂部正中神经浅支进行低强度电刺激可诱发有节奏的手臂运动。此外，额外的外周刺激（如手臂肌肉振动、头部转动或被动有节奏的腿部运动）可增强这些运动。最后，对运动皮层进行低频经颅磁刺激显著促进了节律的产生。这些发现将在用于开发适应性中枢模式发生器调节疗法的脑 - 脊髓接口这一总体框架内进行讨论。
