Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.
Institute for Endemic Disease Prevention and Treatment of Shanxi Province, Linfen, Shanxi, China.
Biol Trace Elem Res. 2019 Dec;192(2):136-144. doi: 10.1007/s12011-019-01668-9. Epub 2019 Feb 23.
To understand the effects of excess iodine intake on blood glucose, blood pressure, and blood lipids in adults. We selected three villages from Shanxi Province to conduct cross-sectional survey: Maxi [median water iodine concentration (MWIC) 6.3 μg/L, median urinary iodine concentration (MUIC) 126.6 μg/L, 320 adults]; Xiwenzhuang (MWIC 79.8 μg/L, MUIC 221.2 μg/L, 264 adults); and Gaoche (MWIC 506.0 μg/L, MUIC 421.3 μg/L, 241 adults). According to the urinary iodine levels in adults, the three villages were defined as iodine-adequate, iodine-sufficient, and iodine-excess. Urinary iodine, water iodine, thyroid function, blood glucose, blood pressure, and blood lipids were measured. Compared with the iodine-adequate area, blood glucose and systolic and diastolic pressure of adults in iodine-sufficient and iodine-excess areas increased and high-density lipoprotein-cholesterol decreased (all P < 0.001). Urinary iodine, thyroid-stimulating hormone, and free thyroxine have a nonlinear correlation with blood glucose (R = 0.8174, 0.8264, and 0.8520, respectively). Excessive iodine intake may result in elevated blood glucose and blood pressure and has some influence on blood lipids, and may increase the risk of hypertension and diabetes.
为了了解成年人碘过量对血糖、血压和血脂的影响。我们从山西省选择了三个村庄进行横断面调查：麻底村（MWIC6.3μg/L，MUIC126.6μg/L，320 名成年人）；西文庄（MWIC79.8μg/L，MUIC221.2μg/L，264 名成年人）；和高车村（MWIC506.0μg/L，MUIC421.3μg/L，241 名成年人）。根据成年人的尿碘水平，这三个村庄被定义为碘充足、碘过量和碘充足。测量了尿碘、水碘、甲状腺功能、血糖、血压和血脂。与碘充足地区相比，碘充足和碘过量地区成年人的血糖和收缩压、舒张压升高，高密度脂蛋白胆固醇降低（均 P<0.001）。尿碘、促甲状腺激素和游离甲状腺素与血糖呈非线性相关（R=0.8174、0.8264 和 0.8520）。碘摄入过多可能导致血糖和血压升高，并对血脂有一定影响，可能增加高血压和糖尿病的风险。
