Liu Z Y, Wang D L
Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
Zhonghua Shao Shang Za Zhi. 2019 Feb 20;35(2):153-156. doi: 10.3760/cma.j.issn.1009-2587.2019.02.012.
Pressure ulcer is localized damage to the skin and subcutaneous tissue usually over a bony prominence as a result of prolonged pressure, shear force, and friction. The effect of external force on soft tissue is affected by many factors, such as local microenvironment, tissue blood supply, nutritional status, and underlying diseases of patients. Although great efforts have been made by mankind to prevent and treat pressure ulcer in last decades, its prevalence is still high, and the curative effect is still not impressive. The treatment of pressure ulcer is a challenge today, and it is necessary to seek new treatment methods. However, the prerequisite for exploring new treatment methods is to find a proper animal model and further explore new therapies through animal experiments. The pathogenesis of pressure ulcer is complex, and the formation process is affected by a variety of factors. To date, there is no recognized standard animal model. We review the pathogenesis of pressure ulcer and the recently reported animal models of pressure ulcer, so as to provide basic experimental basis for further research on the occurrence, development, and prevention of pressure ulcer.
压疮是指皮肤和皮下组织的局限性损伤，通常发生在骨隆突处，是长期压力、剪切力和摩擦力作用的结果。外力对软组织的影响受多种因素制约，如局部微环境、组织血液供应、营养状况以及患者的基础疾病等。尽管在过去几十年中人类为预防和治疗压疮付出了巨大努力，但其患病率仍然很高，治疗效果也仍不尽如人意。如今，压疮的治疗是一项挑战，有必要探寻新的治疗方法。然而，探索新治疗方法的前提是找到合适的动物模型，并通过动物实验进一步探索新疗法。压疮的发病机制复杂，其形成过程受多种因素影响。迄今为止，尚无公认的标准动物模型。我们综述了压疮的发病机制以及近期报道的压疮动物模型，以期为进一步研究压疮的发生、发展及预防提供基础实验依据。
