在一个全国性的HIV退伍军人患者队列中，质子泵抑制剂的使用与低镁血症风险之间的关联。
The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia in a National Cohort of Veteran Patients with HIV.
作者信息
Sutton S Scott, Magagnoli Joseph, Cummings Tammy, Hardin James W
机构信息
1 Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina, College of Pharmacy, Columbia, SC, USA.
2 Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC, USA.
出版信息
J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958218821652. doi: 10.1177/2325958218821652.
OBJECTIVES
To examine the risk of hypomagnesemia of HIV-positive patients adherent to proton pump inhibitors (PPIs).
METHODS
A cohort study utilizing the Veterans Affairs Informatics and Computing Infrastructure was conducted on patients with (1) a complete antiretroviral therapy, (2) a serum magnesium measure during the study period, and (3) adherent to PPIs. Statistical analyses evaluated baseline characteristics between cohorts and a Cox proportional hazards model evaluating the association of hypomagnesemia while adjusting for baseline covariates.
RESULTS
A total of 6047 patients met the study inclusion criteria, 329 patients in the PPI cohort and 5718 patients in the non-PPI cohort. The stratified Cox proportional hazards model results revealed that the risk of hypomagnesemia for the PPI cohort is 3.16 times higher compared to the non-PPI cohort (adjusted hazard ratio = 3.16, 95% confidence interval = 2.56-3.9).
CONCLUSIONS
Proton pump inhibitors medication usage in HIV-positive patients is associated with a higher risk of hypomagnesemia compared to non-PPI patients.
目的
研究坚持使用质子泵抑制剂（PPI）的HIV阳性患者发生低镁血症的风险。
方法
利用退伍军人事务部信息学和计算基础设施进行了一项队列研究，研究对象为满足以下条件的患者：（1）接受完整的抗逆转录病毒治疗；（2）在研究期间进行过血清镁测量；（3）坚持使用PPI。统计分析评估了队列之间的基线特征，并采用Cox比例风险模型评估低镁血症的相关性，同时对基线协变量进行了调整。
结果
共有6047例患者符合研究纳入标准，其中PPI队列329例，非PPI队列5718例。分层Cox比例风险模型结果显示，PPI队列发生低镁血症的风险比非PPI队列高3.16倍（调整后风险比=3.16，95%置信区间=2.56-3.9）。
结论
与未使用PPI的患者相比，HIV阳性患者使用质子泵抑制剂与发生低镁血症的较高风险相关。
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