Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany; Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany.
Med Hypotheses. 2019 Mar;124:35-36. doi: 10.1016/j.mehy.2019.01.020. Epub 2019 Jan 24.
Surfactants are complex mixtures of phospholipids and proteins produced by type II alveolar cells of the lungs and play a crucial role in pulmonary physiology. Six types of surfactant proteins (SP) are known; SP-A, SP-B, SP-C, SP-D, SP-G and SP-H. The major role of SP is in reducing surface tension and various immunological functions. SP-A, SP-B, SP-C and SP-D have been demonstrated in the tear film and the epithelium of the lacrimal sac (LS) and nasolacrimal ducts (NLD). All surfactant proteins except SP-G were also isolated from the canalicular tissues. The authors hypothesize that surfactant proteins play a significant role in the pathogenesis of lacrimal drainage disorders; functional nasolacrimal duct obstruction (FNLDO) and infective dacryocystitis.
表面活性剂是由肺的 II 型肺泡细胞产生的复杂磷脂和蛋白质混合物，在肺生理学中起着至关重要的作用。目前已知有六种表面活性剂蛋白（SP）：SP-A、SP-B、SP-C、SP-D、SP-G 和 SP-H。SP 的主要作用是降低表面张力和发挥各种免疫功能。SP-A、SP-B、SP-C 和 SP-D 已在泪膜和泪囊 (LS) 和鼻泪管 (NLD) 的上皮细胞中得到证实。除 SP-G 外，所有表面活性剂蛋白都可从泪小管组织中分离出来。作者假设表面活性剂蛋白在泪液引流障碍（功能性鼻泪管阻塞 [FNLDO] 和感染性泪囊炎）的发病机制中起重要作用。
