Bout D, Joseph M, Pontet M, Vorng H, Deslée D, Capron A
Science. 1986 Jan 10;231(4734):153-6. doi: 10.1126/science.3079916.
In rats infected with the parasite Schistosoma mansoni, the concentration of C-reactive protein in the serum increases after the lung stage of infection and is at its highest at the time of terminal worm rejection. The peak of platelet-mediated cytotoxicity induced by infected serum that has been heated (and is free of immunoglobulin E) as well as the time course for the development of platelet cytotoxic activity in infected rats was found to be correlated with the concentration of C-reactive protein. Rat and human platelets treated with homologous serum obtained during an acute phase of inflammation or with purified C-reactive protein were able to kill the immature forms of the worm in vitro. Platelets treated with C-reactive protein were furthermore capable of conferring significant protection against schistosomiasis in transfer experiments. Collectively these data indicate that a system that includes C-reactive protein and platelets participates in the natural resistance of the rat to schistosomal infection.
在感染曼氏血吸虫寄生虫的大鼠中，血清中C反应蛋白的浓度在感染的肺部阶段后升高，并在末期蠕虫被清除时达到最高。发现经加热（且不含免疫球蛋白E）的感染血清诱导的血小板介导的细胞毒性峰值以及感染大鼠中血小板细胞毒性活性的发展时间进程与C反应蛋白的浓度相关。用炎症急性期获得的同源血清或纯化的C反应蛋白处理的大鼠和人血小板能够在体外杀死未成熟的蠕虫形式。此外，在转移实验中，用C反应蛋白处理的血小板能够对血吸虫病提供显著的保护。这些数据共同表明，一个包括C反应蛋白和血小板的系统参与了大鼠对血吸虫感染的天然抵抗力。
