转移源自循环肿瘤细胞簇。
Metastasis Stemming from Circulating Tumor Cell Clusters.
机构信息
Department of Stem Cell Biology and Regenerative Medicine, and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Trends Cell Biol. 2019 Apr;29(4):275-276. doi: 10.1016/j.tcb.2019.02.001. Epub 2019 Feb 21.
Abstract
Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of 'stemness' in CTC clusters.
摘要
循环肿瘤细胞（CTC）簇与单个细胞相比，具有更强的转移起始能力，但目前尚不清楚它们如何获得这种优势。Gkountela 等人最近的一项研究（Cell 2019;176:98-112）将簇的物理状态与干细胞相关转录因子的可及性增加联系起来，为 CTC 簇中“干性”的表观遗传调控提供了新的见解。
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