Eriguchi Makoto, Iida Kotaro, Ikeda Shuhei, Osoegawa Manabu, Nishioka Kenya, Hattori Nobutaka, Nagayama Hiroshi, Hara Hideo
Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan.
Osoegawa Neurology clinic, Japan.
Intern Med. 2019 Jul 1;58(13):1935-1938. doi: 10.2169/internalmedicine.2028-18. Epub 2019 Feb 25.
We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa and the presence of levodopa-induced dyskinesia without strong non-motor symptoms were seen in this patient. We considered that young-onset atypical parkinsonism was associated with a history of sublethal glyphosate ingestion. Epidemiologic investigations have shown that exposure to pesticides is a risk factor for Parkinson's disease (PD). Our findings support the notion that glyphosate exposure might be related to the onset of PD.
我们在此报告一例38岁男性病例，该患者在摄入草甘膦4年后出现帕金森症。患者表现为右侧运动迟缓及齿轮样强直，无自主神经症状。脑部磁共振成像及[I] - 间碘苄胍心肌闪烁显像均正常。该患者对左旋多巴有显著反应，且存在左旋多巴诱发的异动症，但无强烈的非运动症状。我们认为青年起病的非典型帕金森症与亚致死量草甘膦摄入史有关。流行病学调查表明，接触杀虫剂是帕金森病（PD）的一个危险因素。我们的研究结果支持草甘膦接触可能与PD发病有关这一观点
