美托洛尔和索他洛尔长期治疗对经食管心房起搏测量的心室复极的影响。
Effect of long term treatment with metoprolol and sotalol on ventricular repolarisation measured by use of transoesophageal atrial pacing.
作者信息
Blomström-Lundqvist C, Dohnal M, Hirsch I, Lindblad A, Hjalmarson A, Olsson S B, Edvardsson N
出版信息
Br Heart J. 1986 Feb;55(2):181-6. doi: 10.1136/hrt.55.2.181.
The effects of long term (4 weeks) treatment with oral metoprolol (100 mg twice daily) and sotalol (160 mg twice daily) on ventricular repolarisation time were compared in a double blind crossover study in 20 patients post-infarction. For QT interval studies transoesophageal atrial pacing was performed at a cycle length of 800 ms. Sotalol prolonged the QT interval by 5-7% compared with metoprolol. The prolongation reflects a change in the repolarisation time because there was no change in the QS interval. Measurements of heart rate at rest and during bicycle exercise indicated that metoprolol and sotalol in the doses selected were equipotent as beta blockers. Transoesophageal atrial pacing is a simple non-invasive method with few and mild side effects that is well suited to drug studies.
在一项针对20名心肌梗死后患者的双盲交叉研究中，比较了长期（4周）口服美托洛尔（每日两次，每次100毫克）和索他洛尔（每日两次，每次160毫克）对心室复极时间的影响。对于QT间期研究，经食管心房起搏以800毫秒的周期长度进行。与美托洛尔相比，索他洛尔使QT间期延长了5 - 7%。这种延长反映了复极时间的变化，因为QS间期没有改变。静息和自行车运动时的心率测量表明，所选剂量的美托洛尔和索他洛尔作为β受体阻滞剂具有同等效力。经食管心房起搏是一种简单的非侵入性方法，副作用少且轻微，非常适合药物研究。
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