Ophoff N, Toker Y
Sektion Kardiologie, Vincenz-Krankenhaus Essen.
Z Kardiol. 1988 Jun;77(6):393-7.
A case of QT prolongation and ventricular tachyarrhythmia in a 57-year-old patient treated with small therapeutic doses of sotalol is reported. There was no concomitant treatment prolonging the QT interval. Hypokalemia could be excluded. Before treatment an electrophysiological study was performed, and ventricular tachycardia could not be initiated. Coronary artery disease was excluded. QT prolongation and ventricular tachyarrhythmias induced by small therapeutic doses of sotalol in normokalemia may occur on rare occasions. It may be problematic to differentiate between torsade de pointes and polymorphous ventricular tachycardia when describing such a ventricular tachyarrhythmia.
报告了1例57岁患者使用小治疗剂量索他洛尔后出现QT间期延长和室性快速心律失常的病例。不存在延长QT间期的合并治疗。可排除低钾血症。治疗前进行了电生理研究，未诱发室性心动过速。排除了冠状动脉疾病。在正常血钾情况下，小治疗剂量索他洛尔引起的QT间期延长和室性快速心律失常可能偶尔发生。在描述这种室性快速心律失常时，鉴别尖端扭转型室速和多形性室性心动过速可能存在困难。
