[多氯联苯再诱导大鼠肝微粒体中的单加氧酶系统活性及脂质过氧化速率]
[Monooxygenase system activity and rate of lipid peroxidation in rat liver microsomes in reinduction with polychlorinated biphenyls].
作者信息
Tutel'ian V A, Khan A V, Lashneva N V, Sorokovaia G K, Gadzhieva Z M
出版信息
Biull Eksp Biol Med. 1986 Jan;101(1):38-40.
PMID:3080035
Abstract
Single oral administration of sovol (mixture of polychlorinated diphenyls) caused a significant induction of the liver monooxygenase system (MOS) in rats. The inducing effect persisted for 5 months. Liver MOS responses were similar in repeated and primary sovol administrations. Differences in the morphological liver changes have been detected following single and repeated administrations of sovol.
摘要
单次口服索沃尔（多氯联苯混合物）可显著诱导大鼠肝脏单加氧酶系统（MOS）。诱导作用持续了5个月。重复给药和初次给药时肝脏MOS的反应相似。单次和重复给予索沃尔后，已检测到肝脏形态变化的差异。
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