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极重度高钠血症和高渗状态后发生的脑桥外髓鞘溶解症。

Extrapontine Myelinolysis following Extreme Hypernatremia and Hyperosmolarity.

作者信息

Schwade Jan-Niclas, Haftel Lior, Rühe Lars, Endmann Matthias

机构信息

Klinik für Kinder-und Jugendmedizin, Evangelisches Krankenhaus Lippstadt, Wiedenbrückerstr. 33, 59555 Lippstadt, Germany.

Radiologische Gemeinschaftspraxis am Evangelischen Krankenhaus Lippstadt, Wiedenbrückerstr. 33, 59555 Lippstadt, Germany.

出版信息

Case Rep Pediatr. 2019 Jan 17;2019:7381597. doi: 10.1155/2019/7381597. eCollection 2019.

DOI:10.1155/2019/7381597
PMID:30800484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6360061/
Abstract

We present a case of a nearly 3-year-old girl who was admitted to hospital due to severe hypernatremia (196 mmol/l). Her medical history included central hypothyreosis and growth hormone deficiency. Rehydration and normalization of sodium was achieved according to guidelines. On the fourth day of hospitalization, the patient developed tremor, ataxia, and rigor. Cranial magnetic resonance imaging (cMRI) was performed and (mis)interpreted for meningoencephalitis, with corresponding diagnostic and therapeutic implications. The patient had extrapontine myelinolysis. The child recovered completely after hospitalization for nearly 2 weeks.

摘要

我们报告一例近3岁女童因严重高钠血症(196 mmol/L)入院。她的病史包括中枢性甲状腺功能减退和生长激素缺乏。根据指南进行了补液和钠的纠正。住院第四天,患者出现震颤、共济失调和强直。进行了头颅磁共振成像(cMRI)检查,并被误诊为脑膜脑炎,从而产生了相应的诊断和治疗后果。该患者患有脑桥外髓鞘溶解症。患儿住院近2周后完全康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/911833b5d9c2/CRIPE2019-7381597.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/30a6ab4a4ab4/CRIPE2019-7381597.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/c83ed5fa490a/CRIPE2019-7381597.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/fc8feb272906/CRIPE2019-7381597.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/911833b5d9c2/CRIPE2019-7381597.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/30a6ab4a4ab4/CRIPE2019-7381597.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/c83ed5fa490a/CRIPE2019-7381597.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/fc8feb272906/CRIPE2019-7381597.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ac/6360061/911833b5d9c2/CRIPE2019-7381597.004.jpg

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本文引用的文献

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Extrapontine Myelinolysis in a Child with Salt Intoxication.一名盐中毒儿童的脑桥外髓鞘溶解症
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Extrapontine myelinolysis associated with severe hypernatremia in infancy.婴儿期严重高钠血症相关的脑桥外髓鞘溶解症
Pediatr Int. 2016 Sep;58(9):936-9. doi: 10.1111/ped.13042. Epub 2016 Jul 27.
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J Child Neurol. 1999 Jul;14(7):428-33. doi: 10.1177/088307389901400704.
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