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本文引用的文献

1
Empagliflozin Treatment Is Associated With Improved β-Cell Function in Type 2 Diabetes Mellitus.恩格列净治疗与 2 型糖尿病患者的胰岛β细胞功能改善相关。
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1402-1407. doi: 10.1210/jc.2017-01838.
2
Sodium-glucose cotransporter-2 inhibition improves incretin sensitivity of pancreatic β-cells in people with type 2 diabetes.钠-葡萄糖共转运蛋白 2 抑制剂可改善 2 型糖尿病患者胰岛β细胞的肠促胰岛素敏感性。
Diabetes Obes Metab. 2018 Feb;20(2):370-377. doi: 10.1111/dom.13081. Epub 2017 Oct 2.
3
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.卡格列净与 2 型糖尿病的心血管和肾脏事件。
N Engl J Med. 2017 Aug 17;377(7):644-657. doi: 10.1056/NEJMoa1611925. Epub 2017 Jun 12.
4
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.恩格列净通过促进脂肪利用和棕色化以及通过极化 M2 巨噬细胞来减轻炎症和胰岛素抵抗，从而抑制 SGLT2。在饮食诱导肥胖的小鼠中。
EBioMedicine. 2017 Jun;20:137-149. doi: 10.1016/j.ebiom.2017.05.028. Epub 2017 May 26.
5
Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin.达格列净可降低2型糖尿病患者的小而密低密度脂蛋白胆固醇水平，并升高高密度脂蛋白2胆固醇水平：与西格列汀的比较。
Cardiovasc Diabetol. 2017 Jan 13;16(1):8. doi: 10.1186/s12933-016-0491-5.
6
Increased Hematocrit During Sodium-Glucose Cotransporter 2 Inhibitor Therapy Indicates Recovery of Tubulointerstitial Function in Diabetic Kidneys.钠-葡萄糖协同转运蛋白2抑制剂治疗期间血细胞比容升高表明糖尿病肾病肾小管间质功能恢复
J Clin Med Res. 2016 Dec;8(12):844-847. doi: 10.14740/jocmr2760w. Epub 2016 Oct 26.
7
CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis.在 EMPA-REG OUTCOME 试验中对 CV 进行保护：“节俭型底物”假说。
Diabetes Care. 2016 Jul;39(7):1108-14. doi: 10.2337/dc16-0330.
8
The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes.钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂恩格列净对1型糖尿病患者胰岛β细胞量及葡萄糖稳态的影响
PLoS One. 2016 Jan 25;11(1):e0147391. doi: 10.1371/journal.pone.0147391. eCollection 2016.
9
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.胰岛素产生减少可缓解内质网应激并诱导β细胞增殖。
Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.
10
Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂鲁格列净对肥胖2型糖尿病db/db小鼠胰腺β细胞的保护作用
Biochem Biophys Res Commun. 2016 Feb 12;470(3):772-782. doi: 10.1016/j.bbrc.2015.10.109. Epub 2015 Oct 23.

SGLT2 inhibitors and protection against pancreatic beta cell failure.

作者信息

Asahara Shun-Ichiro, Ogawa Wataru

机构信息

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017 Japan.

出版信息

Diabetol Int. 2018 Sep 17;10(1):1-2. doi: 10.1007/s13340-018-0374-y. eCollection 2019 Jan.

DOI:10.1007/s13340-018-0374-y
PMID:30800558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6357236/
Abstract
摘要