麦角酸二乙酰胺（LSD）与5-羟色氨酸（5-HTP）：耐受性及交叉耐受性的关系
LSD and 5-HTP: tolerance and cross-tolerance relationships.
作者信息
Carter R B, Appel J B
出版信息
Eur J Pharmacol. 1978 Jul 15;50(2):145-8. doi: 10.1016/0014-2999(78)90010-9.
PMID:308008
Abstract
Tolerance and cross-tolerance relationships between lysergic acid diethylamide (LSD) and 5-hydroxytryptophan (5-HTP) were studied in rats trained on an operant task. The results demonstrated that behavioral tolerance to both compounds occur in the rat and that asymmetrical cross-tolerance relationships exist; that is, animals tolerant to 5-HTP were cross-tolerant to LSD, but animals tolerant to LSD were not cross-tolerant to 5-HTP.
摘要
在接受操作性任务训练的大鼠中研究了麦角酸二乙酰胺（LSD）和5-羟色氨酸（5-HTP）之间的耐受性和交叉耐受性关系。结果表明，大鼠对这两种化合物均产生行为耐受性，且存在不对称的交叉耐受性关系；也就是说，对5-HTP耐受的动物对LSD也具有交叉耐受性，但对LSD耐受的动物对5-HTP不具有交叉耐受性。
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