口服依替膦酸二钠对佩吉特病的短期有效治疗
Effective short term treatment of Paget's disease with oral etidronate.
作者信息
Preston C J, Yates A J, Beneton M N, Russell R G, Gray R E, Smith R, Kanis J A
出版信息
Br Med J (Clin Res Ed). 1986 Jan 11;292(6513):79-80. doi: 10.1136/bmj.292.6513.79.
Abstract
Twelve patients with Paget's disease of bone were treated with high doses of disodium etidronate for one month and compared with patients given treatments for longer periods. The effects of treatment for one month with etidronate 20 mg/kg daily were indistinguishable from six months' continuous treatment with the same dose but significantly better than treatment with 5 mg/kg daily in suppressing biochemical indices of disease activity. Treatment for one month was associated with transient osteomalacia but sustained suppression of bone resorption. Short term treatments with high doses of disodium etidronate may maximise suppression of disease activity but decrease exposure to unwanted effects.
摘要
12名骨佩吉特病患者接受了高剂量依替膦酸二钠治疗1个月，并与接受更长疗程治疗的患者进行了比较。每天20mg/kg依替膦酸治疗1个月的效果与相同剂量连续治疗6个月的效果无明显差异，但在抑制疾病活动的生化指标方面明显优于每天5mg/kg的治疗。1个月的治疗与短暂性骨软化症相关，但能持续抑制骨吸收。高剂量依替膦酸二钠短期治疗可能最大限度地抑制疾病活动，但减少了不良反应的暴露。
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Changes in the renal and extrarenal handling of phosphate induced by disodium etidronate (EHDP) in man.依替膦酸二钠（EHDP）对人体肾脏及肾外磷酸盐处理的影响。
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