Donnelly Callum G, Sones Jenny L, Dockweiler Jenna C, Norberg Lauren A, Norberg Lindsey E, Cheong Soon H, Gilbert Robert O
Am J Vet Res. 2019 Mar;80(3):306-310. doi: 10.2460/ajvr.80.3.306.
OBJECTIVE To evaluate use of flunixin meglumine as a treatment to postpone ovulation in mares, mare fertility after flunixin meglumine treatment during estrous cycles, and effects of flunixin meglumine on function of the corpus luteum after ovulation. ANIMALS 13 healthy mares. PROCEDURES A single-blinded, placebo-controlled, crossover study was conducted. Flunixin meglumine (1.1 mg/kg, IV, q 24 h) or lactated Ringer solution (placebo treatment) was administered for 2 days to mares with a dominant follicle (≥ 35 mm in diameter) and behavioral signs of estrus. Mares then were bred by artificial insemination. Number of days to ovulation from initial detection of a follicle ≥ 30 mm in diameter, uterine edema score, and pregnancy were determined by ultrasonography; the examiner was unaware of the treatment of each mare. Serum progesterone concentrations were evaluated 5 and 12 days after ovulation by use of radioimmunoassay. RESULTS Data were available for 45 estrus cycles of the 13 mares. Number of days to ovulation from initial detection of a follicle ≥ 30 mm was not significantly affected by administration of flunixin meglumine versus the placebo. Per-cycle pregnancy rate was not significantly different between flunixin meglumine (20/24 [83%] breedings) and the placebo (13/19 [68%] breedings). Flunixin meglumine did not significantly affect behavioral signs of estrus, uterine edema, or serum progesterone concentrations. CONCLUSIONS AND CLINICAL RELEVANCE Findings did not support the use of flunixin meglumine to postpone ovulation in mares.
目的 评估氟尼辛葡甲胺用于推迟母马排卵的治疗效果、在发情周期中使用氟尼辛葡甲胺治疗后母马的繁殖力，以及氟尼辛葡甲胺对排卵后黄体功能的影响。动物 13 匹健康母马。方法 进行一项单盲、安慰剂对照的交叉研究。对有优势卵泡（直径≥35 mm）且有发情行为迹象的母马，静脉注射氟尼辛葡甲胺（1.1 mg/kg，每24小时1次）或乳酸林格液（安慰剂治疗），持续2天。然后对母马进行人工授精。通过超声检查确定从最初检测到直径≥30 mm的卵泡到排卵的天数、子宫水肿评分和妊娠情况；检查者不知道每匹母马的治疗情况。在排卵后5天和12天，采用放射免疫分析法评估血清孕酮浓度。结果 13匹母马的45个发情周期有数据可用。与安慰剂相比，氟尼辛葡甲胺的给药对从最初检测到直径≥30 mm的卵泡到排卵的天数没有显著影响。氟尼辛葡甲胺组（24次配种中有20次[83%]）和安慰剂组（19次配种中有13次[68%]）的每周期妊娠率没有显著差异。氟尼辛葡甲胺对发情行为迹象、子宫水肿或血清孕酮浓度没有显著影响。结论和临床意义 研究结果不支持使用氟尼辛葡甲胺推迟母马排卵。
