Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Int J Gynaecol Obstet. 2019 May;145(2):176-181. doi: 10.1002/ijgo.12796. Epub 2019 Mar 13.
To compare serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) concentrations among women with pre-eclampsia and healthy control women and to evaluate the associations of serum PlGF and sFlt-1 with fetal and uterine artery Doppler indices in pre-eclampsia.
A prospective cross-sectional study of 33 women with pre-eclampsia and 33 normotensive pregnant women attending a university hospital in China between January and November 2014. Serum PlGF and sFlt-1 were assayed by enzyme linked immunosorbent assays. Doppler indices of the uterine artery, umbilical artery, fetal middle cerebral artery, and ductus venosus were measured.
The pulsatility index of the uterine artery was negatively correlated with PlGF (r, -0.487; P=0.004) and positively correlated with sFlt-1 (r, 0.420; P=0.015). Gestational age at birth was positively correlated with PlGF (r, 0.601, P<0.001) and negatively correlated with sFlt-1 (r, -0.568; P=0.001). Birth weight was positively correlated with PlGF (r, 0.555; P=0.001) and negatively correlated with sFlt-1 (r, -0.552; P=0.001). Apgar score was negatively correlated with sFlt-1 (r, -0.427; P=0.017).
Lower PlGF and higher sFlt-1 levels in maternal serum were significantly associated with increased uterine arterial impedance in pre-eclampsia.
比较先兆子痫患者与健康对照孕妇血清胎盘生长因子（PlGF）和可溶性 fms 样酪氨酸激酶-1（sFlt-1）浓度，并评估血清 PlGF 和 sFlt-1 与先兆子痫胎儿和子宫动脉多普勒指数的相关性。
2014 年 1 月至 11 月在中国一所大学医院进行的前瞻性病例对照研究，共纳入 33 例先兆子痫患者和 33 例正常妊娠孕妇。采用酶联免疫吸附试验检测血清 PlGF 和 sFlt-1。测量子宫动脉、脐动脉、胎儿大脑中动脉和静脉导管的多普勒指数。
子宫动脉搏动指数与 PlGF（r，-0.487；P=0.004）呈负相关，与 sFlt-1（r，0.420；P=0.015）呈正相关。出生时的胎龄与 PlGF（r，0.601，P<0.001）呈正相关，与 sFlt-1（r，-0.568；P=0.001）呈负相关。出生体重与 PlGF（r，0.555；P=0.001）呈正相关，与 sFlt-1（r，-0.552；P=0.001）呈负相关。Apgar 评分与 sFlt-1（r，-0.427；P=0.017）呈负相关。
母体血清中 PlGF 水平降低和 sFlt-1 水平升高与先兆子痫患者子宫动脉阻力增加显著相关。
