Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, Beverly Hills, CA, USA.
J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1261-1267. doi: 10.1111/jdv.15522. Epub 2019 Mar 15.
The incidence of non-melanoma skin cancer (NMSC) is dramatically increasing worldwide, despite the increased use of improved sunscreens. In 2014, the Surgeon General estimated that 2.2-5.0 million people were treated annually for NMSC. As the number of newly diagnosed skin cancers continues to rise, there is a need for additional preventative measures beyond sunscreens. Several newer topical products that focus on boosting DNA repair, modulating DNA transcription, decreasing inflammation and selectively targeting precancerous cells may play an important role in future skin cancer prevention.
非黑色素瘤皮肤癌（NMSC）的发病率在全球范围内显著增加，尽管人们越来越多地使用改良防晒霜。2014 年，外科医生估计每年有 220 万至 500 万人因 NMSC 接受治疗。随着新诊断出的皮肤癌数量继续上升，除了防晒霜之外，还需要采取其他预防措施。几种新型的局部用产品专注于增强 DNA 修复、调节 DNA 转录、减少炎症和选择性针对癌前细胞，可能在未来的皮肤癌预防中发挥重要作用。
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