Department of Surgery, The Breast Center, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Breast J. 2019 Mar;25(2):278-281. doi: 10.1111/tbj.13207. Epub 2019 Feb 22.
The use of wire localization (WL) for excisions of nonpalpable breast cancer (NBC) has several disadvantages. The purpose of this study was to evaluate the use of indocyanine green-guided nonpalpable breast cancer lesion localization (INBCL) and to compare it with WL. A total of 62 patients with a preoperative histological diagnosis of NBC lesions that could be visualized with ultrasound and mammography were randomized to INBCL or WL. Patients with preoperatively diagnosed primary ductal carcinoma in situ and multifocal disease were excluded from the study. Significance was considered at P < 0.05. Of all 62 excision, 32 (51.6%) were guided by INBCL and 30 (48.4%) by WL. Both techniques resulted in 100% retrieval of the lesions. The rate of clear margins was significantly higher in the INBCL group (87.5%; 28/32) compared to the WL (63.3%, 19/30) (P = 0.026), reducing the requirement of re-excision. When results of the excised tissue are taken into account, the mean volume of the INBCL specimen was 56 cm less than that of the WL group, although this was not significantly different (P = 0.058). INBCL for NBCs was more accurate than WL, because it optimized the surgeon's ability to obtain clear margins. A smaller volume of the tissue may be excised by using INBCL technique. Therefore INBCL is an attractive alternative to WL.
导丝定位（WL）在切除不可触及乳腺癌（NBC）方面存在一些缺点。本研究旨在评估吲哚菁绿引导的不可触及乳腺癌病变定位（INBCL）的使用，并将其与 WL 进行比较。共有 62 名术前超声和乳腺 X 线摄影可显示 NBC 病变的患者被随机分为 INBCL 组或 WL 组。研究排除了术前诊断为原发性导管原位癌和多发病灶的患者。认为 P < 0.05 具有统计学意义。在所有 62 例切除术中，32 例（51.6%）采用 INBCL 引导，30 例（48.4%）采用 WL 引导。两种技术均能 100%获取病变。INBCL 组的切缘清晰率明显高于 WL 组（87.5%，28/32）（P = 0.026），减少了再次切除的需要。当考虑切除组织的结果时，INBCL 组标本的平均体积比 WL 组少 56cm，但差异无统计学意义（P = 0.058）。与 WL 相比，INBCL 用于 NBC 更准确，因为它优化了外科医生获得清晰切缘的能力。使用 INBCL 技术可切除的组织体积更小。因此，INBCL 是 WL 的一种有吸引力的替代方法。
