Leung F W, Miller J C, Guth P H
Dig Dis Sci. 1986 Feb;31(2 Suppl):86S-90S. doi: 10.1007/BF01309329.
Misoprostol, a synthetic prostaglandin analog, has been reported to inhibit gastric acid secretion and to protect the gastric mucosa from the effects of aspirin and aspirin plus hemorrhagic shock. This study examined the effect of misoprostol on basal gastric corpus mucosal blood flow (MBF), and on pentagastrin-stimulated gastric acid output and MBF. Gastric corpus MBF in ml/min/100 g was measured by hydrogen gas clearance in fasted, anesthetized rats. Acid output in mueq/min was determined by a continuous gastric perfusion technique. For the basal study, vehicle or misoprostol in doses of 50 and 1000 micrograms/kg was administered intragastrically in separate groups of rats. For the pentagastrin-stimulation study, vehicle or misoprostol, 1000 micrograms/kg, was infused intravenously after gastric acid output was stimulated to plateau by intravenous pentagastrin, 20 micrograms/kg/hr. The results showed that misoprostol had no effect on basal gastric corpus MBF. During pentagastrin stimulation, misoprostol decreased acid secretion but did not decrease gastric corpus MBF. We speculate that this dissociated effect of misoprostol on stimulated gastric acid secretion and corpus MBF may be of therapeutic importance if it can be confirmed in human studies.
米索前列醇是一种合成的前列腺素类似物，据报道它能抑制胃酸分泌，并保护胃黏膜免受阿司匹林以及阿司匹林加失血性休克的影响。本研究检测了米索前列醇对基础胃体黏膜血流量（MBF）以及对五肽胃泌素刺激的胃酸分泌量和MBF的影响。通过氢气清除法在禁食、麻醉的大鼠中测量胃体MBF，单位为毫升/分钟/100克。通过连续胃灌注技术测定胃酸分泌量，单位为微当量/分钟。在基础研究中，分别给不同组的大鼠胃内给予溶媒或剂量为50和1000微克/千克的米索前列醇。在五肽胃泌素刺激研究中，在通过静脉注射20微克/千克/小时的五肽胃泌素使胃酸分泌量达到稳定水平后，静脉注射溶媒或1000微克/千克的米索前列醇。结果显示，米索前列醇对基础胃体MBF无影响。在五肽胃泌素刺激期间，米索前列醇减少了胃酸分泌，但未降低胃体MBF。我们推测，如果在人体研究中得到证实，米索前列醇对刺激胃酸分泌和胃体MBF的这种分离效应可能具有治疗意义。
