Leung F W, Guth P H
Am J Physiol. 1985 Mar;248(3 Pt 1):G337-41. doi: 10.1152/ajpgi.1985.248.3.G337.
Somatostatin has been reported to control upper gastrointestinal hemorrhage, prevent restraint stress-induced gastric ulcerations, and inhibit gastric acid secretion. In this study we examined the effect of somatostatin on basal and pentagastrin-stimulated gastric acid output and mucosal blood flow. Antral and corpus mucosal blood flows were measured by hydrogen gas clearance in fasted, anesthetized rats. Acid output was determined by a continuous gastric perfusion technique. In the basal study somatostatin in doses of 8, 16, and 32 micrograms . kg-1 . h-1 was infused intravenously in separate groups of animals. In the pentagastrin stimulation study somatostatin (16 micrograms . kg-1 . h-1) was infused after gastric acid output was stimulated to plateau by intravenous pentagastrin (19.8 micrograms . kg-1 . h-1). The results showed that somatostatin had no effect on basal corpus or antral mucosal blood flow. During pentagastrin stimulation somatostatin decreased acid secretion but increased corpus mucosal blood flow. We speculate that this increase in blood flow may not be a direct effect as basal corpus or antral mucosal blood flow was unaffected by somatostatin.
据报道，生长抑素可控制上消化道出血、预防束缚应激诱导的胃溃疡并抑制胃酸分泌。在本研究中，我们检测了生长抑素对基础胃酸分泌以及五肽胃泌素刺激的胃酸分泌和黏膜血流量的影响。在禁食、麻醉的大鼠中，通过氢气清除法测量胃窦和胃体的黏膜血流量。胃酸分泌量通过连续胃灌注技术测定。在基础研究中，分别向不同组动物静脉输注剂量为8、16和32微克·千克⁻¹·小时⁻¹的生长抑素。在五肽胃泌素刺激研究中，在通过静脉输注五肽胃泌素（19.8微克·千克⁻¹·小时⁻¹）使胃酸分泌量刺激至平台期后，输注生长抑素（16微克·千克⁻¹·小时⁻¹）。结果显示，生长抑素对基础状态下的胃体或胃窦黏膜血流量无影响。在五肽胃泌素刺激期间，生长抑素减少胃酸分泌，但增加胃体黏膜血流量。我们推测，这种血流量增加可能不是直接作用，因为生长抑素对基础状态下的胃体或胃窦黏膜血流量没有影响。
