Chen Zhefan Stephen, Chan Ho Yin Edwin
School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong Special Administration Region, China.
School of Life Sciences, Faculty of Science; Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong Special Administration Region, China.
Neural Regen Res. 2019 Jul;14(7):1148-1151. doi: 10.4103/1673-5374.251193.
Yin Yang 1 (YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types, including neurons. It controls neuronal differentiation, as well as neuronal specification and migration during the development of the mammalian nervous system. Besides, YY1 also mediates the transcription of genes that are required for neuronal survival. An impairment of the transcriptional function of YY1 causes neuronal death. This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders. The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms, including recruitment to protein aggregates, protein degradation and aberrant nuclear/cytoplasmic shuttling. Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.
阴阳1（YY1）是一种多功能转录因子，可调节包括神经元在内的多种细胞类型中的基因表达。它控制神经元分化以及哺乳动物神经系统发育过程中的神经元特化和迁移。此外，YY1还介导神经元存活所需基因的转录。YY1转录功能的损害会导致神经元死亡。本综述总结了最近的研究发现，这些发现揭示了YY1在多种神经退行性疾病中的功能障碍。疾病蛋白的表达通过不同的分子机制扰乱YY1的功能，包括募集到蛋白聚集体、蛋白质降解和异常的核/质穿梭。了解YY1的致病作用将进一步拓宽我们对不同神经退行性疾病发病机制的认识。
