Pabian-Jewuła Sylwia, Bragiel-Pieczonka Aneta, Rylski Marcin
Department of Clinical Cytology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Radiology, Institute of Psychiatry and Neurology, Warsaw, Poland.
J Neurochem. 2022 May;161(3):236-253. doi: 10.1111/jnc.15594. Epub 2022 Mar 6.
Herein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple neuropathological actions being involved in the induction of many brain disorders like stroke, epilepsy, Alzheimer's and Parkinson's diseases, autism spectrum disorder, dystonia, and brain tumors. A better understanding of YY1's dysfunction in the nervous system may lead to the development of novel therapeutic strategies related to YY1's actions.
在此，我们讨论了有关转录因子阴阳1（YY1）参与脑部疾病发展的数据，重点介绍了其病理作用机制。YY1在神经系统的发育和成人病理学中发挥着重要作用。YY1对于神经胚形成以及神经元祖细胞和少突胶质细胞的维持与分化至关重要，它调节着大脑的神经组织和胶质组织。YY1基因的缺失会导致中枢神经系统（CNS）出现许多发育异常和解剖畸形。一旦失调，YY1就会发挥多种神经病理作用，参与引发许多脑部疾病，如中风、癫痫、阿尔茨海默病和帕金森病、自闭症谱系障碍、肌张力障碍以及脑肿瘤。更好地了解YY1在神经系统中的功能障碍可能会促成与YY1作用相关的新型治疗策略的开发。
