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肾移植受者人体测量学临床指标及维生素D状况评估:性别间比较

Evaluation of the anthropometric clinical measurements and Vitamin D status in kidney transplant recipients: Comparison between sexes.

作者信息

B Argentino Ana C, Souza Jose F, Dos Santos Sens Yvoty Alves

机构信息

Department of Medicine, Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, SP, Brazil.

Department of Nephrology, Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, SP, Brazil.

出版信息

Saudi J Kidney Dis Transpl. 2019 Jan-Feb;30(1):24-32.

Abstract

Anthropometric clinical indexes have been used to verify the association of obesity with Vitamin D status; however, different reports have yielded conflicting results. The aim of this study was to evaluate the relationship between anthropometric clinical indexes and Vitamin D status in kidney transplant recipients (KTR), comparing by sex. Eighty-five KTR were selected and demographic, clinical, and laboratory data were collected. Anthropometric evaluation using clinical indexes and body composition by bioelectrical impedance analysis were determined, and the patients compared by sex. No differences of serum 1,25-dihy-droxyvitamin D (25(OH)D) values between males and females were found. Females had higher abdominal obesity observed by waist/height ratio and waist/weight ratio, and also higher body fat%, than males. No correlation was found among the 25(OH)D levels and anthropometric data in both sexes. Since serum 25(OH)D concentrations could be influenced by body weight, we also analyzed the 25(OH)D/weight ratio, and this showed an inverse correlation with body mass index (BMI), waist circumference (WC), WC/height ratio, index, conicity index, and body fat%, in females. Moreover, the comparison of the 25(OH)D values among patients classified by BMI showed no differences between sexes. However, the 25(OH)D/weight ratio revealed lower values in overweight and obese patients compared with the normal BMI group, and progressively decreased as the BMI increased, mainly in females. The study suggests that KTR with higher abdominal obesity may need higher Vitamin D intake to obtain adequate serum 25(OH)D status, notably in females.

摘要

人体测量学临床指标已被用于验证肥胖与维生素D状态之间的关联;然而,不同的报告得出了相互矛盾的结果。本研究的目的是评估肾移植受者(KTR)的人体测量学临床指标与维生素D状态之间的关系,并按性别进行比较。选取了85名KTR,收集了人口统计学、临床和实验室数据。通过临床指标进行人体测量评估,并通过生物电阻抗分析测定身体成分,然后按性别对患者进行比较。未发现男性和女性血清1,25-二羟维生素D(25(OH)D)值存在差异。通过腰高比和腰重比观察到女性腹部肥胖程度高于男性,且女性的体脂百分比也高于男性。在两性中,均未发现25(OH)D水平与人体测量数据之间存在相关性。由于血清25(OH)D浓度可能受体重影响,我们还分析了25(OH)D/体重比,结果显示该比值与女性的体重指数(BMI)、腰围(WC)、腰高比、圆锥指数和体脂百分比呈负相关。此外,按BMI分类的患者之间25(OH)D值的比较显示两性之间无差异。然而,与正常BMI组相比,超重和肥胖患者的25(OH)D/体重比显示出较低的值,并且随着BMI的增加而逐渐降低,主要在女性中如此。该研究表明,腹部肥胖程度较高的KTR可能需要更高的维生素D摄入量以获得足够的血清25(OH)D状态,尤其是在女性中。

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