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新西兰北部地区心力衰竭患者心脏再同步治疗的应用情况

Utilization of cardiac resynchronization therapy in patients with heart failure in the Northern Region of New Zealand.

作者信息

Looi Khang-Li, Gavin Andrew, Sidhu Karishma, Cooper Lisa, Dawson Liane, Slipper Debbie, Lever Nigel

机构信息

Green Lane Cardiovascular Service Auckland City Hospital Auckland New Zealand.

Cardiovascular Division North Shore Hospital Auckland New Zealand.

出版信息

J Arrhythm. 2018 Nov 2;35(1):52-60. doi: 10.1002/joa3.12134. eCollection 2019 Feb.

Abstract

BACKGROUND

Cardiac resynchronization therapy (CRT) has been shown to improve morbidity and mortality for heart failure (HF) patients. Little is known about the trends in CRT use and outcomes of these patients in New Zealand.

METHOD

Mortality, hospitalization events and complications in HF patients in the Northern Region of New Zealand implanted with CRT devices from Jan-2007 to June-2015 were reviewed.

RESULTS

Two-hundred patients underwent CRT implantation during the study period. There was a gradual increase in CRT-D implantation (n = 157) but the number remained static for CRT-P (n = 43). Patients who received CRT-P were older (mean age 65.9 ± 14.0 years vs 61.5 ± 10.2 years,  < 0.0007) but had a higher left ventricular ejection fraction (LVEF) (33.7 ± 10.5% vs 24.7 ± 6.1%,  < 0.0001) than those undergoing CRT-D implant procedures. During a median follow-up of 4 (2.8) years, 29 (14.5%) patients (14.7% in CRT-D vs 13.9% in CRT-P,  = 0.91) had died. HF was the cause of death in 73.9% of the patients. There was no difference in all-cause mortality between patients with CRT-D and CRT-P.

CONCLUSIONS

Despite the proven benefits of CRT in selected HF patients, there continued to be under-utilization of these devices in HF patients in the Northern Region. Reasons for under-utilization of these devices need further exploration. These data should be useful for benchmarking individual patient management and national practice against wider experience in the country.

摘要

背景

心脏再同步治疗(CRT)已被证明可改善心力衰竭(HF)患者的发病率和死亡率。在新西兰,关于CRT的使用趋势以及这些患者的治疗结果知之甚少。

方法

回顾了2007年1月至2015年6月在新西兰北部地区植入CRT设备的HF患者的死亡率、住院事件和并发症。

结果

在研究期间,有200名患者接受了CRT植入。CRT-D植入数量逐渐增加(n = 157),但CRT-P植入数量保持不变(n = 43)。接受CRT-P的患者年龄较大(平均年龄65.9±14.0岁 vs 61.5±10.2岁,P<0.0007),但左心室射血分数(LVEF)高于接受CRT-D植入手术的患者(33.7±10.5% vs 24.7±6.1%,P<0.0001)。在中位随访4(2.8)年期间,29名(14.5%)患者死亡(CRT-D组为14.7%,CRT-P组为13.9%,P = 0.91)。73.9%的患者死于心力衰竭。CRT-D组和CRT-P组患者的全因死亡率没有差异。

结论

尽管CRT在特定HF患者中已被证明有益,但在北部地区的HF患者中,这些设备的使用仍然不足。这些设备使用不足的原因需要进一步探索。这些数据对于将个体患者管理和国家实践与该国更广泛的经验进行基准对比应该是有用的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/774a/6373657/de574e766e11/JOA3-35-52-g001.jpg

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