因单日大剂量维生素D（冲击疗法）意外过量摄入丙二醇继发的急性肾衰竭

Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy).

作者信息

Jelley David H, Ali Deborah Zayneb Mohamad, Condren Michelle

机构信息

Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4444 E 41 St., Tulsa, OK 74135, 918-619-4803, USA.

Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4502 E 41 St, Tulsa, OK 74135, 918-660-3400, USA.

出版信息

Case Rep Endocrinol. 2019 Jan 20;2019:1482727. doi: 10.1155/2019/1482727. eCollection 2019.

DOI:10.1155/2019/1482727

PMID:30805225

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6360572/

Abstract

Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. The product label for the vitamin D used for this patient states it is dissolved in propylene glycol (PG), but the amount is not listed on this or other US ergocalciferol liquid products that contain PG. Caution should be used when considering vitamin D stosstherapy with liquid ergocalciferol products available in the United States.

摘要

在全球范围内，维生素D缺乏及其治疗受到了越来越多的关注。大剂量麦角钙化醇单日冲击疗法作为一种潜在的治疗选择正在重新兴起。我们报告了一名接受维生素D冲击疗法治疗的7个月婴儿因丙二醇毒性导致急性肾损伤的尚未报道过的并发症。用于该患者的维生素D产品标签表明其溶解于丙二醇（PG）中，但该产品及其他含PG的美国麦角钙化醇液体制剂均未列出其含量。在考虑使用美国现有的麦角钙化醇液体制剂进行维生素D冲击疗法时应谨慎。