Shima H, Ikoma F, Yabumoto H, Mori M, Satoh Y, Terakawa T, Fukuchi M
J Urol. 1986 Mar;135(3):539-42. doi: 10.1016/s0022-5347(17)45730-2.
Serum levels of luteinizing hormone and follicle-stimulating hormone before and after luteinizing hormone-releasing hormone stimulation, and levels of testosterone before and after 3 days of treatment with human chorionic gonadotropin were determined by radioimmunoassay in 98 boys with hypospadias (2 to 8 years old). The doses of luteinizing hormone-releasing hormone and human chorionic gonadotropin were calculated for body surface. The basal and peak levels of serum luteinizing hormone, follicle-stimulating hormone and testosterone in patients with hypospadias were compared with 9 endocrinologically normal boys of the same age without hypospadias. Luteinizing hormone response to luteinizing hormone-releasing hormone stimulation was significantly impaired in boys with hypospadias and also simple hypospadias (no associated anomaly). Basal levels of luteinizing hormone in boys with simple hypospadias and levels of follicle-stimulating hormone in patients with hypospadias were significantly low. The maximum testosterone response to human chorionic gonadotropin stimulation was significantly decreased in boys with severe hypospadias in direct proportion to the degree of hypospadias.
采用放射免疫分析法测定了98例尿道下裂男孩（2至8岁）促黄体生成素释放激素刺激前后的血清促黄体生成素和促卵泡激素水平，以及人绒毛膜促性腺激素治疗3天前后的睾酮水平。促黄体生成素释放激素和人绒毛膜促性腺激素的剂量根据体表面积计算。将尿道下裂患者血清促黄体生成素、促卵泡激素和睾酮的基础水平及峰值水平与9例同龄无尿道下裂的内分泌正常男孩进行比较。尿道下裂男孩以及单纯尿道下裂（无相关异常）男孩对促黄体生成素释放激素刺激的促黄体生成素反应明显受损。单纯尿道下裂男孩的促黄体生成素基础水平以及尿道下裂患者的促卵泡激素水平显著降低。重度尿道下裂男孩对人绒毛膜促性腺激素刺激的最大睾酮反应明显降低，且与尿道下裂程度成正比。
