Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, 304022, India.
Curr Mol Med. 2019;19(1):12-19. doi: 10.2174/1566524019666190219124301.
Diabetes is a metabolic hyperglycemic condition that progressively develops, effect small and large sensory fibers in the affected population. It has various complications as hypertension, coronary artery disease, stroke, blindness, kidney disease as well as peripheral neuropathy. Sulfonylureas, thiazolidinediones, metformin, biguanidine, acarbose and insulin are commonly used drugs for diabetic patients, but these all have certain side effects. Even metformin, that is known as the miracle drug for diabetes has been found to be associated with side effects, as during treatment it involves complications with eyes, kidneys, peripheral nerves, heart and vasculature. In the present article, we hypothesize recent discoveries with respect to active ingredients from Indian medicinal plants i.e., polypeptide-p (protein analogue act as artificial insulin), charantin (a steroidal saponin), momordicin (an alkaloid) and osmotin (ubiquitous plant protein and animal analogue of human adeponectin) possessing anti-hyperglycemic potential for diabetes type II. Therefore, plants as herbal therapy have preventive care of hyperglycemia accompanied with healthy lifestyle which can provide significant decline in the incidences of diabetes in future.
糖尿病是一种代谢性高血糖病症，会逐渐影响到受影响人群中的小和大感觉纤维。它有各种并发症，如高血压、冠状动脉疾病、中风、失明、肾病以及周围神经病变。磺酰脲类、噻唑烷二酮类、二甲双胍、双胍类、阿卡波糖和胰岛素是常用的糖尿病药物，但这些药物都有一定的副作用。即使是被称为糖尿病“奇迹药物”的二甲双胍，也被发现与副作用有关，因为在治疗过程中它会涉及到眼睛、肾脏、周围神经、心脏和血管的并发症。在本文中，我们假设印度药用植物的活性成分的最新发现，即多肽 -p（作为人工胰岛素的蛋白质类似物）、苦瓜素（甾体皂甙）、苦瓜素（一种生物碱）和 osmotin（普遍存在的植物蛋白和人类脂联素的动物类似物）具有抗 II 型糖尿病的降血糖潜力。因此，植物作为草药疗法具有预防高血糖的作用，并伴随着健康的生活方式，可以显著降低未来糖尿病的发病率。
